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Transcriptional profiling of the kidney glomerulus
(2010-05-20)
model. LPS triggered the specic gene expression pattern changes in the glomerulus and regulated several dierent pathways. We observed that podocyte number decreased signicantly in the model. Moreover, the genes encoded collagen 1, 2 and laminin 2 chains...
Exposure and acceptance in patients with chronic debilitating pain : a behavior therapy model to improve functioning and quality of life
(2009-01-16)
A large number of patients suffer from reduced functioning and quality of
life due to longstanding pain. The importance of psychological factors is
undisputable and there is today substantial empirical support for
treatments ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, elucidating the function of DJ...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
release. Using SUR1(-/-) mice, we unambiguously confirmed the previous notion that the insulinotropic activity of BL11282 is unrelated to its interaction with ATPdependent K+ channels. We have also shown that previously described targets for imidazoline...
Protective factors in childhood allergy related to diet and lifestyle
(2010-05-07)
The prevalence of allergic disease among children has increased markedly during several decades. The reasons behind the increase remain unclear, but lifestyle and environmental factors associated with the Western way of ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
in C-section eosinophils compared to normal delivery eosinophils, here, being IFN-gamma receptor and STAT1. Our RT-PCR data confirms the upregulation of these genes in eosinophils from cord blood compared to normal delivery. This indicates a more...
Systemic stress response and hyperglycemia after abdominal surgery in rat and man
(2008-10-23)
Surgical trauma results in a complex neuroendocrine and metabolic response known as the systemic stress response, which is initiated by neuronal and humoral signals from the site of the injury. These signals converge at ...
Tissue biomarkers in prostate cancer
(2009-09-25)
in PC. A tissue microarray (TMA) of 289 PCs was constructed and immunostained. HSP 27 and 60, but not HSP 70 and PDX-1 correlated with biochemical recurrence. In multivariate analysis including histopathological prognostic factors, only HSP 60...
Mechanisms and effects of low plasminogen activator inhibitor type 1 activity
(2008-09-26)
Bleeding diathesis is a common reason for investigation of the haemostatic system and in about 50% of the cases an abnormality is found. Plasminogen activator inhibitor type 1 (PAI-1) is an inhibitor of tissue- and urokinase plasminogen activator (t...