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Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
This thesis deals mainly with the synthesis of various sulfur/selenium-containing heterocyclic compounds, many of which include structural features present in several biologically active molecules, with particular emphasis ...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
The serotonin receptor type 3 in chronic and experimental human muscle pain
(2010-05-14)
was to investigate if the expression of 5-HT3 receptors in muscle tissue differ between myalgic and healthy muscles and if sex or muscle site influence this expression. The aim for the human experimental part was to investigate if the specific 5-HT3 antagonist...
Asthma treatment in primary care : studies of variability and health economic aspects
(2009-05-15)
Background: Most asthma patients in Sweden are treated in primary care, but little is known about economic aspects of asthma treatment in that setting and about the regional variation in the use of antiasthmatics drugs and ...
Dermal exposure determinants : a pesticide exposure assessment approach for developing countries
(2008-11-26)
Background: We know little about the levels of exposure to pesticide in
subsistence farmers mainly because of lack of easy to use and low cost
pesticide exposure assessment methods.
Aim: This thesis aimed to develop ...
Statistical methods for biomarker discovery in proteomics
(2008-08-15)
Surface-Enhanced Laser Desorption and Ionization (SELDI) is a promising proteomic technique for discovering biomarkers. However, the pre-processing of the raw data is still problematic. Integrating transcriptomic and ...
Transcriptional profiling of the kidney glomerulus
(2010-05-20)
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and ...
Computer-supported diagnosis in psychiatry
(2009-02-20)
support from the system; 5) flexibility for abstract adaptive learning mode was connected to longer time system use; 6) pattern recognition was applied in the deciding situation where hypothetico-deductive reasoning was expected from an evidence...
Epidemiology and care of epilepsy in Vietnam
(2010-05-12)
of active epilepsy were thus identified. Age-adjusted incidence was 44.8/100,000 (95%CI 30.6-59.0), higher in those under 16 years, among people with lower education, and with lower income. Age-adjusted prevalence was 4.4 per 1,000 (95%CI 3.8-5.0), higher...
Development of novel DNA vaccine and immunotherapeutic approaches
(2009-08-06)
Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is ...