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Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
biologically active indolothiopyrans and related selenopyrans, as analogues of indolocarbazoles. The target compounds were accessed via treatment of C-2 metalated indoles with bis(phenylsulfonyl) sulfide or selenide, followed by cyclization of the intermediate...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Synaptic plasticity in local networks of neocortical layer 2/3
(2008-12-26)
-timing dependent plasticity, STDP). We reported that the learning rule governing STDP modification is regulated by preceding activity in a postsynaptic neuron. Moreover, we have shown that the difference between STDP observed at layer 2/3 (L2/3) P-P cell...
Mutations and molecular signatures in human melanoma
(2010-02-05)
. With this work, we wanted to obtain further insights into the biological background of skin melanoma in different stages of progression. We focused on commonly altered pathways and genes, NRAS, BRAF and CDKN2A, and their effects on activation and expression...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
Dynamic ultrasonography in neonatal hip instability and acetabular dysplasia
(2008-09-05)
The clinical hip examination, although highly sensitive in expert hands
in detecting neonatal hip instability, can lead to considerable
overtreatment. Ultrasound is increasingly being used to complement the
clinical ...
Dissemination of Toxoplasma gondii to the central nervous system : with special reference to in vivo bioluminescence imaging
(2009-08-07)
Toxoplasma gondii causes an asymtomatic chronic infection in immune
competent individuals that can be life-threatening in individuals that
become immuno-compromised or to the developing fetus. This thesis aimed
to (1) ...
Studies on hereditary spastic paraplegia proteins
(2010-05-14)
The hereditary spastic paraplegias (HSPs) are a clinically and genetically diverse group of inherited neurological disorders that primarily cause progressive spasticity and weakness in the lower limbs due to a length-dependent, ...
Transcription factor control in neuronal maintenance and survival
(2010-04-16)
The Transcription factor (TF) Nurr1 is essential for the development of a group of dopamine neurons that are located in the ventral midbrain (also referred to as mesencephalon). A progressive pathology of these midbrain ...
Aspects on local recurrence of rectal cancer
(2009-04-09)
Rectal cancer is a common malignant disease in Sweden which is diagnosed in about 1,800 patients annually. Local failure, defined as residual or recurrent disease within the pelvis, is of major concern in rectal cancer ...