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Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce ...
Injury profile and injury risk factors in junior tennis players
(2010-05-28)
-nine players sustained totally 100 new and recurrent injuries, 73 injuries in boys and 27 injuries in girls. Injury incidence for both genders was 2.3 injuries/1000 hours of tennis playing time, for boys 1.7 injuries/1000 hours and for girls 0.6 injuries/1000...
The rehabilitation process after breast cancer diagnosis : factors of importance for return to work
(2008-10-24)
The most common female cancer in Western countries is breast cancer and
women diagnosed with this disease are often under 65 years old. With
increasing prevalence of survivors it is important to shed light on
problems ...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
at baseline in 1995-1996 and evaluated by MRI over a mean period of 9.25 years (range 7.3-10 years) from 1995-2005. Serial brain atrophy measurements (1D and 2D) were analyzed by one radiologist on a routine PACS workstation, and these results were compared...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Sox proteins and neurogenesis
(2010-04-02)
the role of Sox21 in regulating neurogenesis. We show that Sox21 promotes neurogenesis, opposite to the activity of the SoxB1 factors (Sox1-3) that has been shown to repress neurogenesis. Sox21 and Sox1-3 bind a similar set of target genes and the effect...
Traffic noise and cardiovascular disease
(2010-04-30)
to road traffic noise at the residence. The risk appeared particularly high among participants exposed to a combination of road traffic noise, occupational noise and job strain (OR 2.27, 95% CI 1.41 3.64). The association between road traffic noise...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
were ex-amined with kidney tissues of db/db mice. The ADIPOQ gene is located in chromosome 3q27.3. A promoter single nucleotide polymorphism (SNP) rs266729 in the gene was found to be associated with DN in female T1D patients. This polymorphism altered...
Active immunization against nicotine dependence
(2010-03-19)
Tobacco smoking is the largest preventable cause of morbidity and premature mortality in the world. Although its medical consequences are well documented, 20-45% of the adult population in the European countries remains ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...