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Alternative splicing of interleukin-7
(2009-04-03)
to function as either agonists or as antagonists of the wildtype cytokine. Interleukin-7 (IL-7) plays a non-redundant role in early stages of normal B and T-cell development; IL-7-receptor signaling is required for the maintenance of T-cell homeostasis...
Exploring a national practice-based register for the management of rheumatoid arthritis
(2008-10-17)
Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require ...
Active immunization against nicotine dependence
(2010-03-19)
Tobacco smoking is the largest preventable cause of morbidity and premature mortality in the world. Although its medical consequences are well documented, 20-45% of the adult population in the European countries remains ...
Complications and associated conditions of celiac disease
(2008-08-22)
with CD (1964-2003) and 69,967 matched reference individuals. We found that individuals with CD were at increased risk of both subsequent ITP of any type (Hazard ratio (HR) = 1.91; 95% = 1.19-3.11; p = 0.008) and subsequent chronic ITP (HR 2.77; 1.09-7...
Chest wall sarcomas
(2010-03-05)
Aim: To evaluate initial symptoms and clinical features, diagnosis and delay
in osteosarcoma (OS), Ewing sarcoma (EWS) and chest wall chondrosarcoma
(CS). To assess treatment and identify prognostic factors in chest ...
Tobacco smoking, high body mass index and the outcome after surgery : the role of intervention
(2008-11-07)
The negative effects of smoking and obesity on public health are
well-known. Despite this knowledge, the smoking-attributable morbidity
and mortality is estimated to rise rapidly in the forthcoming years, and
obesity ...
Molecular and phenotypic characterization of diarrhoeagenic Escherichia coli from Nicaraguan children
(2009-11-23)
%), followed by vt2-eaeA 1/8 (12.5%) and vt1 1/8 (12.5%) positives, at similar frequencies. In addition, the low diversity (Di=0.829) obtained from PhPRE analysis of EHEC positive samples suggest the presence of pathogenic clonal groups. In addition...
LXR and aromatase knock-out mice : animal models providing insight into human diseases
(2009-01-01)
In our characterization of mouse strains carrying mutations in nuclear
receptor and aromatase genes we have found phenotypes which resemble four
human diseases: benign prostatic hyperplasia (BPH), Sjögren s syndrome
(SS), ...
Development of novel DNA vaccine and immunotherapeutic approaches
(2009-08-06)
Many potential DNA vaccination and immunotherapeutic strategies has been explored in both animal models and human settings in recent years. However, the failure of efficient and safe method development suggests that it is ...
Tissue biomarkers in prostate cancer
(2009-09-25)
Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ...