Search
Now showing items 1-10 of 293
Genetic analysis of type 1 diabetes susceptibilty
(2008-11-21)
. It is thought that both environmental as well as genetic factors act in concert to cause T1D. The HLA region located on chromosome 6 accounts for about 50% of the genetic risk to develop T1D. However, several other genes are also known to contribute to disease...
Statistical genetic analysis of family data
(2008-08-22)
The importance of genetic determinants and risk factors of diseases has been consistently recognized in genetic epidemiology, which is one of the fastest growing areas in genomic medicine. Familial clustering is a common ...
Aciclovir-induced neuropsychiatric symptoms : a clinical pharmacology study
(2010-08-13)
Aciclovir (ACV) and its prodrug valacyclovir (VACV) are used to treat infections caused by herpes simplex virus (HSV) and varicella zoster virus (VZV), and as prophylaxis against cytomegalovirus (CMV) infections in ...
Study of pruritus in psoriasis vulgaris : role of tachykinins
(2009-01-23)
Pruritus has not been considered as the most important symptom of
psoriasis. In the present thesis various methodologies have been used to
investigate this symptom in psoriasis.
The focus groups created a proper ...
Prenatal, socio-demographic and oral hygiene-related risk factors on dental caries and periodontal conditions in adolescents : clinical and register-based studies
(2010-03-05)
The overall aim of these studies was to identify risk determinants for
dental caries and periodontal conditions in adolescents using clinical
and register-based data.
This thesis is based on two parts. Part 1 ...
Studies on female genital tract infections and the role of nitric oxide in diagnosis
(2010-04-16)
Female genital tract infections are among the most common conditions causing individuals to seek medical care, and are associated with a high gynaecologic and reproductive morbidity. Thus, prompt and precise diagnosis of ...
Proteomics in neurological disease
(2009-11-06)
Neurodegenerative and neuroinflammatory diseases are conditions affecting the central nervous system that in the end have dramatic impacts on the affected individuals and their families. Today, large efforts are made to ...
Genetic and immunological mechanisms regulating neuroinflammation
(2010-10-27)
Multiple sclerosis (MS) is the most common neurological disorder in young adults and imposes both health and socioeconomic burdens on society. The cause and aetiology of MS are incompletely understood and current treatments ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Human papillomaviruses and their association with squamous cell carcinoma of the conjunctiva
(2009-10-07)
broad spectrum PCR methods. Results: 14.6% samples tested positive for cutaneous HPV, and no mucosal HPV infection was detected; no excess of HPV infection was found in individuals who had died of HIV/AIDS-related causes as compared to those who had died...