Search
Now showing items 1-10 of 133
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
convenient synthetic routes toward a wide range of 3-(arylthio)indoles in good yields. In an extension, the sulfonation of 1-(phenylsulfonyl)indoles and pyrroles using chlorosulfonic acid in acetonitrile has been studied, leading to development of a simple...
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
Dengue fever (DF) is the most common global viral mosquito-borne infection, with 100 million estimated cases annually in tropical and subtropical areas. The dengue viruses (genus Flavivirus, Flaviviridae) occur in 4 serotypes (DENV-1 to DENV-4...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
-environment interaction between HLA-DRB1 SE alleles and smoking; 2. Gene-gene interaction between HLA-DRB1 SE and R620W PTPN22 alleles; 3. Interaction between alcohol consumption, smoking and HLA-DRB1 SE alleles; and 4. Dose dependency between smoking and risk...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Alcohol and the effect on some appetite-regulating hormones in man
(2008-11-28)
, respectively. Other gut hormones, having central effects as well as influence on intestinal motility, are glucagon-like peptide (GLP-1) and obestatin. Liver derived insulin-like growth factor-1 (IGF-1) and its binding protein insulin-like growth factor binding...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about 13% of the total CYP450...
Autoantibodies in congenital heart block
(2009-11-20)
that heart block develops in rat pups of three strains carrying MHC haplotype RT1av1 (DA, PVG.AV1 and LEW.AV1) after maternal Ro52 immunization, while pups from LEW rats (RT1l) rarely developed block. Different anti-Ro52 antibody fine-specificities were...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
on the cell surface expression of thrombospondin-1 (TSP-1) in T cells. The results demonstrate a chemokine-dependent CD26-controlled regulation of T cell polarity and migration through endogenous TSP-1. Based on the results in the third paper we then studied...
Computer-supported diagnosis in psychiatry
(2009-02-20)
The aim of this thesis was to analyze possibilities and restraints, from a cognitive perspective, of a CDSS for diagnostics in Psychiatry. To benefit from a CDSS for diagnostics, individual variations in cognitive functioning ...