Search
Now showing items 1-10 of 134
Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Platelet dysfunction in diabetes mellitus : impact of hyperglycemia and glycoprotein GPIIb/IIIa inhibition
(2009-02-06)
Diabetes mellitus (DM) is associated with increased cardiovascular
morbidity and mortality, due to diabetic angiopathy. Hyperglycemia is one
of the factors that may cause platelet dysfunction in diabetic patients.
This ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Role of water channels in kidney and lung
(2009-11-27)
assessed urinary AQP2 level in preterm and term infants during the postnatal period. We could demonstrate that urinary AQP2 correlates with the overall maturity of tubular function in human neonates. Urinary AQP2 may reflect AQP2 expression level associated...
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
(2009-05-08)
occurrence of psychoactive plant use in Sweden. Studies were done in attempt to elucidate the metabolic pattern of α- and b-asarone in humans. Cis(b)-2,4,5-trimethoxycinnamic acid was regarded to be the most abundant metabolite, evidence of a hydroxylated...
Development of novel DNA vaccine and immunotherapeutic approaches
(2009-08-06)
and LNA oligomers as "openers" to partially overlapping sites on the opposite DNA strand. This procedure allows hybridization at reduced PNA-to-plasmid ratios, allowing greater than 80% hybridization even at ratios as low as 2:1. Using significantly lower...
The many faces of p57Kip2 : acting in apoptosis, differentiation and cytoskeleton reorganisation
(2009-08-28)
p57Kip2 is a known cyclin dependent kinase inhibitor, which has been suggested to be a tumor suppressor gene. Indeed various human cancers show a reduction in p57Kip2 expression, indicating that this protein might be of relevance in tumorigenesis...
Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
-860) in the aprotinin group vs. 1210 mL (95%CI:860-1550) in the control group (p=0.004). The aprotinin group received fewer transfusions of packed red blood cells (0.9 U, 95%CI:0.1-1.7, vs. 2.7 U, 95% CI:1.4-4.1; p=0.01), platelets (0.1 U, 95%CI:0-0.3, vs. 0.6 U, 0.2- 0...
Living with eczema : a multidisciplinary approach
(2008-11-28)
Background: Eczema is one of the most common diseases in the population,
affecting individuals of all ages. The impact on physical and
psychosocial wellbeing is important. This thesis describes some aspects
of this ...