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Novel experimental targeted therapy of neuroblastoma
(2009-11-12)
TOR. Inhibition of the mTOR signalling pathway with rapamycin (Rapamune®) or its novel analogue CCI-779 (Torisel®) showed promising potential in vitro and in vivo, where the most interesting finding was that MYCN-amplified or over expressing cells were more...
Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators
(2010-01-15)
Medulloblastoma is an embryonal tumour that mainly affects children. It
is the most common malignant brain tumour in children and accounts for
15% of all childhood brain tumours. It most often presents in the
cerebellum ...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Characterization of Gcn5 histone acetyltransferase in Schizosaccharomyces pombe
(2009-08-07)
response. We map genome-wide Gcn5 occupancy and show that Gcn5 is predominantly localized to coding regions of highly transcribed genes. We also map H3K14 acetylation during salt stress and show that Gcn5 collaborates antagonistically with the class...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
The Stockholm-Thessaloniki acute traumatic spinal cord injury study
(2010-01-14)
rate was 33.6/million in Thessaloniki and 19.5/million in Stockholm. Trans-portation in Thessaloniki and falls in Stockholm were the dominant causes of trauma. The two groups were similar with regard to demographic and core clinical characte...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
with tonsillectomy and/or adenoidectomy. Presurgically the OSAS children underwent clinical examination by an otolaryngologist, sleep registration with polysomnography (PSG), and orthodontic examination. Follow-up examinations and registrations were made 1, 3, and 5...