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Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
analogues such as 1-sila-, 1-germa- and 1-selenacyclohepta-2,4,6-trienes containing two fused aromatic or heterocyclic units....
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
(2009-05-08)
The flora of the world contains many plants and fungi with stimulant, hallucinogenic and narcotic effects. For centuries, many of these have been used in initiation rites, physical and spiritual healing and rites of ...
Studies on hereditary spastic paraplegia proteins
(2010-05-14)
The hereditary spastic paraplegias (HSPs) are a clinically and genetically diverse group of inherited neurological disorders that primarily cause progressive spasticity and weakness in the lower limbs due to a length-dependent, ...
Anatomical studies of hypothalamic thyrotropin-releasing hormone : implications for motivated states
(2010-05-14)
The survival of every animal as an organism and species depends on three
motivated states: ingestive, defensive and reproductive. Regulation of
these states is coordinated by the hypothalamus through the coordination
of ...
Stimulus evoked transient dynamics in the primary visual cortex in vivo : voltage sensitive dye and extracellular recordings
(2008-05-22)
In this study we investigated how the primary visual cortex responds to a
change in the visual scene. In analogy to dynamical systems theory such
temporal step input gives information about the rules governing ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Neurotransmitter phenotypes of neurons in the spinal cord and their functional role in the mouse locomotor network
(2010-03-03)
Walking is a special case of movement because it is rhythmic. An important area in current neuroscience research, is to better understand the different organizational levels (molecular, ion channels, neurotransmitters, ...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and ...
Extra- and intracellular electronic conductance of signals and its significance for synaptic plasticity
(2008-08-08)
Electrical signals play a pivotal role in the normal function of most if
not all organisms. Understanding the electrophysiological principles that
govern electrical signaling is essential for insights into normal- ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...