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Isoforms of mammalian glutaredoxin 2
(2009-05-05)
lies upon the question how Grx2 activity is regulated as well as how many isoforms of mammalian glutaredoxin 2 there are. Here, we have characterized human Grx2 as the first iron sulfur centercontaining thiol-disulfide oxidoreductase of the thioredoxin...
Polycyclic aromatic hydrocarbons : DNA damage and cell signaling
(2008-11-28)
Oxidative stress is a threat to our wellbeing. The formation of reactive
oxygen species may result in oxidative lesions in DNA and RNA. When
challenging A549 cells with 18O-labeled hydrogen peroxide, we found that
RNA ...
Traffic noise and cardiovascular disease
(2010-04-30)
to road traffic noise at the residence. The risk appeared particularly high among participants exposed to a combination of road traffic noise, occupational noise and job strain (OR 2.27, 95% CI 1.41 3.64). The association between road traffic noise...
Statin-induced cellular effects mediated by the P2X7 receptor
(2009-05-22)
Cholesterol-lowering statins have been shown to inhibit growth of
different cancer cells both in vitro and in vivo. Epidemiological studies
also indicate a chemopreventive effect of statins. We have investigated
the ...
The Rarebit fovea test : a new measure of visual function
(2008-04-23)
Visual acuity (VA) measurement by the use of letter charts is the most
frequently used method for testing foveal function. However, since a
decimal visual acuity of 1.0, often used as limit for normality, can be
achieved ...
A new technique to assess dermal absorption of chemical vapor in vitro by thermogravimetric analysis (TGA)
(2008-11-28)
vapor (from water, 2-propanol, methanol and toluene). When no chemical vapor was present the weight of the skin was constant and upon addition of chemical vapor the weight of the skin increased until an equilibrium with the surrounding air was reached...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
-environment interaction between HLA-DRB1 SE alleles and smoking; 2. Gene-gene interaction between HLA-DRB1 SE and R620W PTPN22 alleles; 3. Interaction between alcohol consumption, smoking and HLA-DRB1 SE alleles; and 4. Dose dependency between smoking and risk...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
of genes involved in ROS metabolism in EBV positive and negative Burkitt's lymphoma (BL) cell lines and lymphoblastoid cell lines (LCL) we found that the NADPH oxidase (NOX)-2 is induced in cells expressing EBNA-1. Activation of the NOX2 gene by EBNA-1...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
the se-quence for SP1 binding site and subsequently caused the reduction of ADIPOQ promoter activity. The MCF2L2 gene is located in chromosome 3q27.1. A non-synonymous SNP rs7639705 (Leu359Ile) was associated with DN in females. This polymorphism together...
From stem cell to neuron : a Sox perspective
(2010-04-30)
as development proceeds, from the early neural lineage specification in pluripotent stem cells to the gene regulatory control operating in maturing postmitotic neurons. We show that, already in pluripotent stem cells, Sox2 binds to inactive neural genes and that...