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Living with eczema : a multidisciplinary approach
(2008-11-28)
Background: Eczema is one of the most common diseases in the population,
affecting individuals of all ages. The impact on physical and
psychosocial wellbeing is important. This thesis describes some aspects
of this ...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Molecular characterization of Mycobacterium tuberculosis complex isolates from Sweden
(2010-04-21)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex
(MTC), is a serious infection in man and animals. According to the World
Health Organisation (WHO), about one third of the world´s population is
infected ...
Molecular epidemiology of tuberculosis
(2009-05-07)
Tuberculosis (TB) is a global epidemic, with one third of the world's population infected, at least 9 million new active cases per year and about 2 million deaths per year. Without adequate chemotherapy treatment TB may ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
between Env immunogens and CD4-expressing cells would negatively affect the elicitation of Envspecific immune responses, CD4 binding-competent and CD4 binding-defective trimers were constructed and inoculated into non-human primates. No difference...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Mutations and molecular signatures in human melanoma
(2010-02-05)
Cutaneous melanoma is a disease which results from a complex mixture of various extrinsic and intrinsic factors, with some major players still unknown. Although primary tumors are highly curable with surgical excision, ...
Asthma treatment in primary care : studies of variability and health economic aspects
(2009-05-15)
Background: Most asthma patients in Sweden are treated in primary care, but little is known about economic aspects of asthma treatment in that setting and about the regional variation in the use of antiasthmatics drugs and ...
Ultrastructural studies of the blood-urine barrier in proteinuric states
(2010-04-30)
studied. Thorough ultrastuctural analyses at different time-points in PAN were performed. alpha-actinin-4, a cytoskeleton cross-linker, did not change. Nephrin started to decrease on day two after induction, i.e. before the appearance of proteinuria...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...