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Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
This thesis will mainly focus on the chemistry of nitrogen containing heterocyclic compounds, particularly pyrazole and benzotriazine and related ring systems to these compounds. The first part includes a short introduction ...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
The most common cause of OSAS in children is enlarged tonsils and/or adenoids. Consequently, the treatment for OSAS in children with enlarged tonsils and/or adenoids is adeno-/tonsillectomy. The prevalence of OSAS in children is 1-3%, with the peak...
Transcriptional profiling of the kidney glomerulus
(2010-05-20)
The kidney glomerulus plays a crucial role in ultraltration of the blood through the glomerular capillary wall. Glomerulus injury may occur in many systemic and primary kidney diseases or as secondary eects to drugs and ...
Experimental studies of N-methyl-D-aspartate receptor NR3 subunits
(2008-04-25)
This thesis focuses on the NR3A and NR3B subunits of the excitatory
glutamate receptor N-methyl-D-aspartate (NMDA). Functional NMDA receptors
are believed to be tetrameric complexes with combinations of NR1 and NR2
subunits, ...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
at baseline in 1995-1996 and evaluated by MRI over a mean period of 9.25 years (range 7.3-10 years) from 1995-2005. Serial brain atrophy measurements (1D and 2D) were analyzed by one radiologist on a routine PACS workstation, and these results were compared...
The role of the prostate in androgen metabolism
(2009-05-08)
significant 3betaAdiol levels were detected in human prostate tissue (paper IV). The cytochrome P450 7B1 (CYP7B1) enzyme is a putative regulator of intraprostatic 3betaAdiol levels. In paper III we demonstrated increased CYP7B1 protein expression in malignant...
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
(2009-05-08)
The flora of the world contains many plants and fungi with stimulant, hallucinogenic and narcotic effects. For centuries, many of these have been used in initiation rites, physical and spiritual healing and rites of ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Paroxysmal atrial fibrillation : prognostic implications
(2008-08-29)
This thesis is based on data from the Stockholm Cohort on Atrial
Fibrillation (SCAF). This cohort consists of all 2912 patients with
atrial fibrillation or flutter who were treated as in or outpatients at
South Hospital ...
Hazardous alcohol use and alcohol use disorders in women : characteristics and vulnerability factors
(2010-09-17)
The overall aim of this thesis was to study vulnerability factors associated with hazardous alcohol consumption during pregnancy and alcohol use disorders among Swedish women. Different risk-factors and characteristics ...