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Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Cancer vaccine strategies and studies of human thioredoxin reductase splice variants
(2010-05-28)
genomic structure, leading to numerous splice variants. Peculiarly, the v3 splice variant encompasses a unique glutaredoxin domain, transcription of which is guided by an alternative promoter, which is located upstream of the TrxR1 core promoter...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
The most common cause of OSAS in children is enlarged tonsils and/or adenoids. Consequently, the treatment for OSAS in children with enlarged tonsils and/or adenoids is adeno-/tonsillectomy. The prevalence of OSAS in children is 1-3%, with the peak...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
A new computed tomography method for evaluation of orthopedic implants : applied to the acetabular cup
(2009-12-25)
Background: Two major long term complications after total hip
arthroplasty (THA) is aseptic loosening and wear of the implant. In the
clinical situation a detection level of approximately 1 mm is desirable.
However, ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
The syndecans are a four-member family of type I transmembrane proteoglycans. Their core proteins have a short cytoplasmic domain, a transmembrane domain and a large N-terminal extracellular domain possessing glycosaminoglycan ...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
were ex-amined with kidney tissues of db/db mice. The ADIPOQ gene is located in chromosome 3q27.3. A promoter single nucleotide polymorphism (SNP) rs266729 in the gene was found to be associated with DN in female T1D patients. This polymorphism altered...