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The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Suicide and mortality related to mental disorder in three Swedish cohorts
(2010-04-02)
Aims: The subject of this thesis is suicide and other premature death related
to mental disorder. The overall aim is to provide knowledge to improve
prevention strategies. The specific aims are as follows: Study I: ...
On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
(2008-05-15)
histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. In this way, DNA can be tightly packaged in the cell. The N-terminal tails, that protrude out from the histone surfaces can be subjected to different covalent...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Peripheral venous catheters : quality of care assessment
(2009-12-31)
About half of the patients admitted to hospitals receive intravenous
therapy through peripheral venous catheters (PVCs). Unfortunately, the
use of PVCs is associated with the risk of complications that may lead to
increased ...
Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
-860) in the aprotinin group vs. 1210 mL (95%CI:860-1550) in the control group (p=0.004). The aprotinin group received fewer transfusions of packed red blood cells (0.9 U, 95%CI:0.1-1.7, vs. 2.7 U, 95% CI:1.4-4.1; p=0.01), platelets (0.1 U, 95%CI:0-0.3, vs. 0.6 U, 0.2- 0...
Psychopathic personality in adolescence : genetic and environmental influences
(2009-09-04)
Psychopathy, or psychopathic personality, is a personality disorder characterized by a constellation of deviant interpersonal, affective, and behavioral dimensions. It has consistently been shown that the psychopathic ...
Prenatal, socio-demographic and oral hygiene-related risk factors on dental caries and periodontal conditions in adolescents : clinical and register-based studies
(2010-03-05)
The overall aim of these studies was to identify risk determinants for
dental caries and periodontal conditions in adolescents using clinical
and register-based data.
This thesis is based on two parts. Part 1 ...
Studies on the phenotype of LXRβ-/- mice : from malabsorption to amyotrophic lateral sclerosis
(2008-10-06)
Liver X Receptors, LXRalpha and LXRbeta (NR1H2) are nuclear receptors
belonging to the superfamily of ligand-activated transcription factors
with a key role in the control of lipid and glucose metabolism. Studies
of the ...
Manipulating neural stem cells
(2010-03-17)
The stem cell field is a fairly young but fast growing scientific field. Our understanding of stem cells has changed tremendously over the last couple of decades. This in mainly due to the development of new techniques ...