Search
Now showing items 1-10 of 164
Molecular epidemiology of hepatitis A, B and C in Estonia
(2008-04-25)
.5%) were identified. To characterize their subgenotypes complete genomes were sequenced for 13 genotype A and 33 D strains. All genotype A strains belonged to subgenotype A2. The D strains segregated into subgenotypes D1, D2 and D3 where D2 was dominating...
Structural and functional studies on glutaredoxins and members of the thioredoxin superfamily
(2008-12-19)
thiolate was hydrogen bonded to surrounding amide protons and to the thiol proton of Cys14. The Cys14 chi1 and chi2 torsion angles determined by NMR supported the simulation result. The torsion angles of Cys11 could not be determined due to degenerate β...
Identification and validation of therapeutic targets in sarcoma models
(2009-05-21)
mutations. Knowing that HDM2 might have a role in the tumorigenesis of these tumors, we investigated the role of SS18-SSX1 on the function of p53. We found that SS18-SSX1 stabilizes HDM2, thus disrupting the stability and tumor suppressive function of p53...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Ultrastructural studies of the blood-urine barrier in proteinuric states
(2010-04-30)
. Dendrin and plekhh2 decreased on day four when the animals had massive proteinuria. We concluded that a disturbed expression of nephrin in PAN rats, similar to our findings in MCNS, seems to be related to the appearance of proteinuria. Changes in plekhh2...
Body and soul : studies on health and psychosomatic complaints among adolescents in Sweden
(2008-10-07)
Objective: The aim of this thesis is to describe the health of the
adolescents with special emphasis on psychosomatic complaints.
Method: Both quantitative and qualitative methods were used to get a
insight into ...
Genetic and functional analyses of diabetic nephropathy with focus on chromosome 3q
(2010-05-14)
the se-quence for SP1 binding site and subsequently caused the reduction of ADIPOQ promoter activity. The MCF2L2 gene is located in chromosome 3q27.1. A non-synonymous SNP rs7639705 (Leu359Ile) was associated with DN in females. This polymorphism together...
Molecular epidemiology of tuberculosis
(2009-05-07)
Tuberculosis (TB) is a global epidemic, with one third of the world's population infected, at least 9 million new active cases per year and about 2 million deaths per year. Without adequate chemotherapy treatment TB may be a mortal disease...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20...