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The human gastric microbiota in health and disease
(2010-04-16)
aim was to further develop the 454 pyrosequencing as a tool for assessing changes in the human microbiota. Using the 454 pyrosequencing approach PCR-products can be sequenced without prior cloning and sample-specific sequence tags enable sequencing...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
models (HMM), we have identified catalytic domains of ubiquitin specific proteases (deubiquitinating enzymes, DUBs) in a limited number of EBV ORFs. The DUB activity of three high scoring candidates: BPLF1, BSLF1 and BXLF1, was confirmed by functional...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. Syndecans are involved in many cellular processes including cell differentiation, proliferation, adhesion and migration. Syndecan-1 is the prototype and a hybrid...
Pelvic organ prolapse : aspects of etiology, symptomatology and outcome after surgery
(2009-04-17)
The objective of this thesis was to increase the understanding of
symptoms related to pelvic support defects, to study the influence of
non-obstetric risk factors for pelvic organ prolapse, to describe
short-term natural ...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 infected intravenous drug...
Deciphering HIV genetic variability and evolution by massive parallel pyrosequencing and bioinformatics
(2014-05-05)
HIV-1 is a virus with a very variable genome and therefore has the ability to adapt to new environments which include escape from immune pressure and suboptimal antiretroviral treatment. Next-generation sequencing (NGS), especially ultra...
Mechanism of pathological angiogenesis in adipose tissue and tumor
(2009-09-18)
in the adipose tissue affects angiogenesis, vascular patterning and functions. FOXC2 controls angiopoietin-2 (Ang-2) expression by direct activation of its promoter in adipocytes. Remarkably, an Ang-2 specific antagonist L1-10 reverses the vascular alterations...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). The PTCH1 gene is reported to have four first exons and we showed in paper I that PTCH1 is transcriptionally regulated by three independent promoters...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
release. Using SUR1(-/-) mice, we unambiguously confirmed the previous notion that the insulinotropic activity of BL11282 is unrelated to its interaction with ATPdependent K+ channels. We have also shown that previously described targets for imidazoline...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...