Search
Now showing items 1-10 of 318
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient ...
Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...
Immunological studies on anca-associated vasculitis with special reference to T cell activation
(2009-10-16)
on the cell surface expression of thrombospondin-1 (TSP-1) in T cells. The results demonstrate a chemokine-dependent CD26-controlled regulation of T cell polarity and migration through endogenous TSP-1. Based on the results in the third paper we then studied...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). The PTCH1 gene is reported to have four first exons and we showed in paper I that PTCH1 is transcriptionally regulated by three independent promoters...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
models (HMM), we have identified catalytic domains of ubiquitin specific proteases (deubiquitinating enzymes, DUBs) in a limited number of EBV ORFs. The DUB activity of three high scoring candidates: BPLF1, BSLF1 and BXLF1, was confirmed by functional...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Regulation and function of thioredoxin reductase 1 in human tumor cells
(2009-05-22)
The thioredoxin system is a general protein disulfide reductase system
present in all organisms. Its function is to maintain an intracellular
reducing environment and upholding a defense against reactive oxygen
species ...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about 13% of the total CYP450...
Role of genes and environment for the development of rheumatoid arthritis : results from the Swedish EIRA study
(2009-01-09)
-environment interaction between HLA-DRB1 SE alleles and smoking; 2. Gene-gene interaction between HLA-DRB1 SE and R620W PTPN22 alleles; 3. Interaction between alcohol consumption, smoking and HLA-DRB1 SE alleles; and 4. Dose dependency between smoking and risk...
Regulation of the hepatic ACAT2 expression and roles of HNF1alhpa and HNF4alpha in cholesterol metabolism
(2009-11-06)
Acyl-Coenzyme A:cholesterol acyltransferases (ACATs) 1 and 2 are integral membrane proteins located in rough endoplasmatic reticulum that catalyzes the formation of cholesteryl esters (CEs) from cholesterol and long-chain fatty acids. ACAT1...