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Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
affected in a similar way as in the Wnt7a overexpressing embryos. The cell polarity and its effect on the actin cytoskeleton was determined by investigating the monomeric GTPases that are members of the Rho protein family: Rac1 and RhoA. Our results show...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, elucidating the function of DJ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. Syndecans are involved in many cellular processes including cell differentiation, proliferation, adhesion and migration. Syndecan-1 is the prototype and a hybrid...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 infected intravenous drug...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Mechanism of pathological angiogenesis in adipose tissue and tumor
(2009-09-18)
in the adipose tissue affects angiogenesis, vascular patterning and functions. FOXC2 controls angiopoietin-2 (Ang-2) expression by direct activation of its promoter in adipocytes. Remarkably, an Ang-2 specific antagonist L1-10 reverses the vascular alterations...
HIV-1 infection and loss of serological memory : the role of altered expression of B-cell chemokine receptors, timing of HAART and impaired antibody affinity maturation
(2008-12-26)
Currently, big efforts in HIV-1 research are devoted to the design of a
HIV-1 vaccine. However, no successful vaccine is yet available, also due
to the lack of basic knowledge in HIV-1 pathogenesis which is still
profound. ...
In silico analysis of pathways targeted by EBV infection and malignant transformation
(2009-10-23)
models (HMM), we have identified catalytic domains of ubiquitin specific proteases (deubiquitinating enzymes, DUBs) in a limited number of EBV ORFs. The DUB activity of three high scoring candidates: BPLF1, BSLF1 and BXLF1, was confirmed by functional...
Blocking interleukin-1 signalling in the brain-structural and functional outcomes
(2008-10-07)
The aims of this thesis were to evaluate the consequences of blocking interleukin (IL)-1 signalling in the brain. The studies used a transgenic mouse model with brain-directed overexpression of the human soluble isoform of IL-1 receptor antagonist...
Applications of nanotechnology in neuroscience : functionalized superparamagnetic nanoparticles as contrast enhancers in experimental magnetic resonance imaging
(2010-04-08)
Magnetic resonance imaging (MRI) is a noninvasive imaging technique that
helps clinicians not only to diagnose but also to plan the treatment of
invasive surgery and actually treat medical conditions. Superparamagnetic
iron ...