Search
Now showing items 1-10 of 293
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
convalescent samples (<6 weeks), complemented by late convalescent samples (>5 years) from 20 patients, previously serotyped by PCR were included in the study. The correct serotype was determined in 80% (16/20) of the late convalescent samples, while...
Genetic content of clinical pneumococcal isolates and its relation to disease outcome
(2009-09-30)
carriage or invasiveness. No obvious candidate was found. ARs 6 and 34 were found in most of the invasive isolates and were absent in most of the isolates of low invasive disease potential and were tested for invasiveness in a mouse model of infection. We...
Drug-related problems with special emphasis on drug : drug interactions
(2009-09-04)
-patients and to determine whether a pharmacotherapeutic advisory intervention aiming at reducing DRPs could affect rates of re-hospitalisation and / or death within 6 months. A total of 299 DRPs among 71% (106/150) of the patients were found, who had not previously been...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Structural maintenance of chromsomes : a complex tale of genomic integrity
(2009-04-03)
Genomic integrity is an absolute requirement for cell survival.
Programmed events such as genome rearrangements and DNA replication can
cause lesions in the DNA, as can exogenous agents such as radiation and
chemicals. ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Muscle mass and function after total hip arthroplasty
(2009-04-17)
with unilateral OA were assessed preoperatively, 6 months and two years after THA for strength of hip and knee muscles, gait, postural control and clinical scores (HHS, SF-36, EQ-5D). Also, CSA and RD of hip, thigh, calf and back muscles were assessed using CT...
Proximal femoral fractures : functional outcome, quality of life and mortality
(2008-11-27)
A hip fracture in the elderly is one of the most devastating consequences
of osteoporosis and has a high rate of complications, including death and
a serious threat to the patient s future mobility, social functioning,
quality ...
Antiproliferative action of estrogen receptor beta and Hes-1 in breast cancer
(2008-10-23)
for endocrine therapy. In this thesis, focus is on the second estrogen receptor, ERbeta and its function in breast cancer. In addition, the significance of the transcription factors Hes-1 and Hes-6 in breast cancer and their relation to ERa has been studied...
Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe
(2010-05-27)
The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around ...