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Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
-cell interactions of committed ectodermal cells. We also showed that expression of the Wnt PCP signalling gene Vangl2 (Van gogh-like 2) was increased. Wnt7a´s influence on neuronal differentiation was studied by investigation of β-tubulin III expression, a marker...
Post-traumatic stress disorder and resilience in children of traumatised parents
(2008-05-13)
group without torture experiences, and the children in both groups. The traumatised parents' group consisted of 15 families where either one or both of the parents had a history of torture (30 parents, fathers' mean age 43.5 years, mothers' 38.7 years...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...
Eosinophilic dermatosis implications of skin-commensal bacteria and antimicrobial peptides and proteins at birth
(2009-08-28)
At birth, the newborn infant is transferred from a sterile life in utero to an earthly life in coexistence with microbes. This transition includes the potential danger of a microbial invasion through the epithelial linings, ...
Myocardial infarction and diabetes mellitus : studies on glucose lowering therapies and novel risk markers based on observations from the DIGAMI 2 trial
(2010-05-14)
Background: Patients with myocardial infarction (MI) and type 2 diabetes (T2DM) and
have a poor prognosis. Hyperglycemia is an independent risk predictor.
The best tools for glucose control are debated. Important ...
Mechanism of pathological angiogenesis in adipose tissue and tumor
(2009-09-18)
and further investigation of mechanism of angiogenesis in adipose tissue metabolism and cancer development. Multiple factors spatiotemporally regulate adipogenesis and angiogenesis. In a transgenic mouse model described in the first constituent paper, FOXC2...
Statin-induced cellular effects mediated by the P2X7 receptor
(2009-05-22)
Cholesterol-lowering statins have been shown to inhibit growth of
different cancer cells both in vitro and in vivo. Epidemiological studies
also indicate a chemopreventive effect of statins. We have investigated
the ...
Regulation of transcription factors by XAP-2 : a member of the Hsp90 chaperone complex
(2008-08-29)
The AhR belongs to the bHLH/PAS family of transcription factors, which
mediates biological effects of environmental pollutants such as
2,3,7,8-tetrachlorodibenzo-rho-dioxin (TCDD). In the absence of ligand
the AhR is ...
The p53-induced Wig-1 protein : studies of interaction partners and expression in tumor cells
(2008-09-04)
The tumor suppressor p53 is a critical regulator of life and death in
cells. The p53 protein is present at very low levels in cells under
normal conditions but accumulates in response to different stress
stimuli, such ...