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The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Biomarkers of suicide risk in psychosis
(2009-11-27)
was to investigate the long-term suicide risk in schizophrenia spectrum psychosis, whether concentrations of the CSF monoamine metabolites 5-hydroxyindoleacetic acid (5-HIAA) and homovanillic acid (HVA) are related to suicidal behavior and to the overall mortality...
Biosynthesis and biological role of leukotrienes in human lymphocytes
(2009-04-09)
Leukotrienes (LT) are biologically active metabolites of arachidonic acid. The key enzyme in leukotriene biosynthesis is 5-lipoxygenase (5-LO). Leukotriene B4 exerts its biological effect mainly via BLT1, the high affinity receptor for LTB4...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Exploring a national practice-based register for the management of rheumatoid arthritis
(2008-10-17)
Rheumatoid arthritis (RA) is a chronic, inflammatory, auto-immune disease with an unpredictable and debilitating course. From diagnosis and onward, RA patients who need treatment with anti-rheumatic drugs will require ...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
We developed a novel, pure glucose-dependent, insulinotropic imidazoline compound, BL11282, which directly affects the insulin exocytotic machinery and does not block the KATP channel activity. BL11282 does not induce ...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...
Epidemiology and care of epilepsy in Vietnam
(2010-05-12)
of active epilepsy were thus identified. Age-adjusted incidence was 44.8/100,000 (95%CI 30.6-59.0), higher in those under 16 years, among people with lower education, and with lower income. Age-adjusted prevalence was 4.4 per 1,000 (95%CI 3.8-5.0), higher...
On diagnostic procedures in pulmonary embolism
(2008-10-03)
-dimer <0.5 mg/L, to determine whether the score and test safely exclude VTE and whether a follow-up D-dimer test measured 3-7 days after admission adds extra information. The patients were followed for three months. A follow-up D-dimer was available for 67...