Search
Now showing items 1-10 of 300
Turning guidelines into clinical practice : findings from an implementation study
(2010-05-19)
Aim: The general aim of this thesis is to describe factors of importance
when implementing clinical guidelines in psychiatry, and more
specifically contribute to a better understanding of the implementation
process. The ...
Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Causal inference in epidemiological research
(2009-01-16)
Traditionally, statistics has been viewed as the branch of science which
deals with association. Many epidemiological research questions, however,
are concerned with causation, not association. In this thesis we ...
Activities with balance limitations among patients with perpheral arthritis : description and assessment
(2008-08-25)
Background and aim: Patients with peripheral arthritis (PA) have several
impairments that can influence balance and be risk factors for falls and
fear of falling. Since disability varies among these patients, we need ...
Development of PET radioligands synthesized from in-target produced [11C]methane
(2010-02-08)
). The second aim was to apply high SA [11C]CH4 in the development of PET radioligands for CNS targets such as the metabotropic glutamate receptor 5 (mGluR5), β-amyloid aggregates and the serotonin 1B (5-HT1B) receptor system. PET is a molecular imaging...
Ligand binding and mechanism of microsomal glutathione transferase 1
(2009-01-09)
spectrometry, binding of three GSH molecules was observed within the trimer while the monomer did not bind GSH, in agreement to the proposed binding sites at subunit interfaces (Holm, et al., (2006). J. Mol. Biol. 360(5): 934-945). The binding of GSH could...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
with tonsillectomy and/or adenoidectomy. Presurgically the OSAS children underwent clinical examination by an otolaryngologist, sleep registration with polysomnography (PSG), and orthodontic examination. Follow-up examinations and registrations were made 1, 3, and 5...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient ...