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Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. Syndecans are involved in many cellular processes including cell differentiation, proliferation, adhesion and migration. Syndecan-1 is the prototype and a hybrid...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
It has been almost 30 years since the identification of HIV as the causative agent of AIDS. Despite considerable efforts to halt the spread of the virus, the epidemic continues in many parts of the world. The most efficient ...
Postpartum psychosis and the association with sociodemographic and obstetric factors
(2009-01-30)
Objective: To examine the association between postpartum psychosis and the
sociodemographic factors age, education, marital status and year of
delivery (study 1). To examine the association between neighbourhood
socioeconomic ...
Regulation of Hedgehog signalling during development and carcinogenesis
(2009-11-26)
commonly arises due to mutations in the gene sequence of the Hh receptor protein PATCHED1 (PTCH1). The PTCH1 gene is reported to have four first exons and we showed in paper I that PTCH1 is transcriptionally regulated by three independent promoters...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
release. Using SUR1(-/-) mice, we unambiguously confirmed the previous notion that the insulinotropic activity of BL11282 is unrelated to its interaction with ATPdependent K+ channels. We have also shown that previously described targets for imidazoline...
Regulation of gene expression by non-protein-coding RNAs
(2009-01-29)
The human genome sequencing projects revealed that the human genome contains over 3 billion DNA base pairs, but only 20,000 25,000 protein-coding genes. In fact, only about 1.2% of the genome codes for proteins. Surprisingly, the number of human...
Injury profile and injury risk factors in junior tennis players
(2010-05-28)
-nine players sustained totally 100 new and recurrent injuries, 73 injuries in boys and 27 injuries in girls. Injury incidence for both genders was 2.3 injuries/1000 hours of tennis playing time, for boys 1.7 injuries/1000 hours and for girls 0.6 injuries/1000...
TGF-beta signaling in carcinogenic transformation of breast epithelial cells, using proteomics
(2008-09-18)
of these cell lines. In a systemic and network analysis, we identified a number of novel TGFbeta-dependent pathways, whose regulation is pivotal for TGFbeta signaling in breast carcinogenesis. We focused on one such pathway (PLAG1-CNK1-RASSF1A) involved...