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Prevention and intervention therapies in auditory trauma
(2009-01-16)
Hearing impairment is one of the most common health conditions in
developed countries. It is estimated that approximately 70 million people
worldwide are deaf. For patients with a severe to profound hearing loss a
cochlear ...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Dissection of HIV-1 Env-specific B cell responses in non-human primates
(2010-04-27)
between Env immunogens and CD4-expressing cells would negatively affect the elicitation of Envspecific immune responses, CD4 binding-competent and CD4 binding-defective trimers were constructed and inoculated into non-human primates. No difference...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
that reflect MTA. In the MRI study (Papers 3&4), 544 healthy non-demented subjects (aged 60-97 years) were recruited from the Swedish National study of Aging and Care in Kungsholmen (SNAC-K). Hippocampal formation and entorhinal cortex were manually delineated...
Experimental combination therapy of brain cancer cell models
(2012-11-21)
. Mono-therapy using HDACi sodium 4-PB induced minor cell killing effects in neither of the analyzed cell lines. Similar results were observed after mono-therapy using gefitinib or vandetanib. However the combination of 4-PB with gefitinib resulted...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Studies on leukotriene B4 and alarmins in inflammatory responses
(2010-01-29)
Leukotriene B4 (LTB4) is a potent proinflammatory lipid mediator that is involved in host defense and inflammatory diseases, such as atherosclerosis. LL-37 and heparin binding protein (HBP) are cationic antimicrobial polypeptides, which belong...
A longitudinal study of dentofacial morphology in young children treated for the obstructive sleep apnoea syndrome
(2008-09-19)
The most common cause of OSAS in children is enlarged tonsils and/or adenoids. Consequently, the treatment for OSAS in children with enlarged tonsils and/or adenoids is adeno-/tonsillectomy. The prevalence of OSAS in ...
Transcriptional control of CD4+ T lymphocytes
(2009-05-08)
The immune system can respond to various types of pathogens such as
bacteria, viruses, tumors and parasites. The ability to provide
protection against different types of pathogens partly relies on
development of alternative ...
Storage and transfusion of platelets : in vitro and in vivo studies in healthy volunteers and in allogeneic hemapoetic progenitor cell transplant recipents
(2009-03-13)
Early studies in the 1960´s showed that platelet (PLT) transfusions
significantly reduced the incidence of fatal hemorrhages. Together with
the advances in the hematology and transplantation field, easily
accessible ...