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Isoforms of mammalian glutaredoxin 2
(2009-05-05)
lies upon the question how Grx2 activity is regulated as well as how many isoforms of mammalian glutaredoxin 2 there are. Here, we have characterized human Grx2 as the first iron sulfur centercontaining thiol-disulfide oxidoreductase of the thioredoxin...
Calcium signaling : molecular mechanisms and cellular consequences
(2008-11-21)
Cells exploit calcium (Ca2+) signaling to transmit information. In a
multicellular organism, each cell must be able recognize, process, and
respond to information received from the surrounding environment. In this
thesis ...
Mechanism of pure glucose-dependent insulinotropic activity of a novel imidazoline compound BL11282
(2008-05-01)
potentiation of insulin release by this peptide. The latter effect points to the importance of GLP-1 stimulated signal-transduction pathways for the insulinotropic activity of BL11282. Our results support the involvement of the cAMP-GEFII·Rim2 pathway in BL...
Synaptic plasticity in local networks of neocortical layer 2/3
(2008-12-26)
-timing dependent plasticity, STDP). We reported that the learning rule governing STDP modification is regulated by preceding activity in a postsynaptic neuron. Moreover, we have shown that the difference between STDP observed at layer 2/3 (L2/3) P-P cell...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
The aim of this project is to describe the pattern of innate immunity responses at birth with focus on the recruitment of leukocytes such as eosinophils and neutrophils and their content of cathelicidin antimicrobial peptide ...
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(2010-04-30)
) ml/min/1.73 m2 and 33% had at least moderate renal dysfunction. Patients with lower renal function differed by being older and having more co-morbidities. They presented less often with chest pain and ST-elevation MI. After adjustments, lower renal...
Study of pruritus in psoriasis vulgaris : role of tachykinins
(2009-01-23)
Pruritus has not been considered as the most important symptom of
psoriasis. In the present thesis various methodologies have been used to
investigate this symptom in psoriasis.
The focus groups created a proper ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Characterization of dopamine D1 receptor agonists in vivo : implications for the treatment of schizophrenia and Parkinson's disease
(2008-05-14)
Dopamine is fundamental in human behavior for movement, cognition and
reward. A dysfunctional dopamine system is implicated in several
neurological and psychiatric disorders such as Parkinson s disease and
schizophrenia. ...