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Chromosome aberrations and environmental exposures in acute leukemia
(2009-08-19)
distribution): 2-554, (P=0.002), in all different professions exposed to organic solvents: OR: 4.9; 95%CI: 2.2-12.1, (P<0.001) and in drivers: OR: 3.0, 95%CI: 1.1-9.2 (P=0.02). Multivariate analysis showed that the significances remained, after consideration...
Rheumatoid arthritis as a modifier of periodontitis
(2007-01-19)
Periodontitis is a chronic tissue-destructive condition in which the
tooth-supporting collagen fibers of ligament and bone are broken down
mainly by the host s overreactive immune inflammatory response. The
relation between ...
Art of tumor immunity : extricating hypoxia-driven immunosuppression in the solid tumor microenvironment
(2023-09-20)
suppressive effects, leading to reduced regulatory T cells, improved IFN production and decreased PD-1 and TIM-3 expression in CD8 T cell. In Paper IV, we explored the myeloid cell compartment in PDAC using a 3D spheroid model and a quantitative secretome...
Genetic and functional studies of MTTP and PLIN2 in relation to metabolic and cardiac dysfunction
(2012-04-24)
Lipids including triglycerides, cholesterol, cholesterol esters and fatty acids are important sources for energy production, act as building blocks for intracellular compartments, are involved in numerous biological pathways ...
Hormonal regulation of HES-1 in breast cancer cells
(2008-05-21)
, coactivators and corepressors were recruited to this cis-element in response to estrogen. Importantly, a decrease in acetylation of histone H3 and H4 and a decrease in recruitment of RNA POL II were observed, indicating a repression of HES-1 expression...