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Polycyclic aromatic hydrocarbons : DNA damage and cell signaling
(2008-11-28)
Oxidative stress is a threat to our wellbeing. The formation of reactive
oxygen species may result in oxidative lesions in DNA and RNA. When
challenging A549 cells with 18O-labeled hydrogen peroxide, we found that
RNA ...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Epigenic regulation and posttranslational modification of human cytochrome P450s : focus on CYP2W1, CYP1A2 and CYP2C18
(2008-11-21)
The cytochrome P450 superfamily represents a very important group of
enzymes that are responsible for the metabolism of drugs as well as of
endogenous compounds. Many P450s are genetically polymorphic causing
important ...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about 13% of the total CYP450...
Studies of cannabinoid receptor 1 in mantle cell lymphoma
(2008-11-21)
Mantle cell lymphoma (MCL) is a malignant B-cell lymphoma that affects
older individuals and has a male predominance. MCL has one of the worst
prognoses among lymphomas and currently there is a search for a curative
therapy. ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
(2009-05-08)
occurrence of psychoactive plant use in Sweden. Studies were done in attempt to elucidate the metabolic pattern of α- and b-asarone in humans. Cis(b)-2,4,5-trimethoxycinnamic acid was regarded to be the most abundant metabolite, evidence of a hydroxylated...
Mechanism of pathological angiogenesis in adipose tissue and tumor
(2009-09-18)
and further investigation of mechanism of angiogenesis in adipose tissue metabolism and cancer development. Multiple factors spatiotemporally regulate adipogenesis and angiogenesis. In a transgenic mouse model described in the first constituent paper, FOXC2...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Role of water channels in kidney and lung
(2009-11-27)
assessed urinary AQP2 level in preterm and term infants during the postnatal period. We could demonstrate that urinary AQP2 correlates with the overall maturity of tubular function in human neonates. Urinary AQP2 may reflect AQP2 expression level associated...