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Turning guidelines into clinical practice : findings from an implementation study
(2010-05-19)
Aim: The general aim of this thesis is to describe factors of importance
when implementing clinical guidelines in psychiatry, and more
specifically contribute to a better understanding of the implementation
process. The ...
Risk management : the role of clinical factors in violent behaviour
(2009-12-25)
Background: The relationship between clinical factors and reoffending in
psychiatric and correctional populations is unclear, with a lot of
contradictory results and some clinical areas lacking in research. The
overall ...
Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, elucidating the function of DJ...
HIV-1 genotype and vertical transmission in northern Vietnam
(2008-10-28)
After 18 years from the beginning of the HIV-1/AIDS epidemic in Vietnam, the number of HIV-1 infected individuals is still increasing. Investigations conducted at two distinct time points in two separate groups of HIV-1 infected intravenous drug...
Studies on syndecan-1 in mesenchymal tumors
(2010-01-08)
the protein domains and the glycosaminoglycan chains can contribute to the functions of syndecans. Syndecans are involved in many cellular processes including cell differentiation, proliferation, adhesion and migration. Syndecan-1 is the prototype and a hybrid...
Development of cannabinoid subtype-1 (CB1) receptor ligands for PET
(2008-05-23)
Introduction: Abnormalities in brain cannabinoid subtype-1 (CB1) receptor
concentrations and/or signaling pathways may be involved in a variety of
psychiatric and neurodegenerative disorders. There is a strong need ...
Endogenous thrombospondin-1 and proteases in the regulation of lymphocyte adhesion and motility
(2008-09-26)
lipoprotein receptor-related protein (LRP)/CD91. Interaction of TSP-1 with its cell surface receptors calreticulin (CRT), LRP and integrin associated protein (IAP)/CD47 was promoting motility of T cells in 3D collagen through CD47. T cell surface TSP-1 also...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about 13% of the total CYP450...