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CD8alpha/alpha+ T-cells and immune memory
(2009-04-29)
A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co...
Structural and biophysical studies of pneumococcal capsular surface proteins
(2014-10-15)
region of PsrP (BR187-385) reveals an extended β-sheet on one side of a compressed two-sided β-barrel presents a basic groove that could accommodate the acidic helical rod domain of KRT10. Well-ordered loop regions distort the other side of the barrel...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
blood count, in particular neutrophils and monocytes, as well as an enhanced IL-8 and soluble ESelectin level. Assisted delivery, associated with the highest degree of fetal stress in addition has an increased Interferon-gamma level. The direct...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Kaposi's sarcoma and malignant lymphomas in Tanzania during the AIDS epidemic
(2009-02-27)
Kaposi s sarcoma (KS) studies Kaposi´s sarcoma (KS) is the most frequent AIDS tumor (AKS) and associated with HHV-8, but controversial whether a clonal tumor or mostly a reactive proliferation of endothelial spindle cells (SC). In the present...
The Rarebit fovea test : a new measure of visual function
(2008-04-23)
Visual acuity (VA) measurement by the use of letter charts is the most
frequently used method for testing foveal function. However, since a
decimal visual acuity of 1.0, often used as limit for normality, can be
achieved ...
Tobacco smoking, high body mass index and the outcome after surgery : the role of intervention
(2008-11-07)
The negative effects of smoking and obesity on public health are
well-known. Despite this knowledge, the smoking-attributable morbidity
and mortality is estimated to rise rapidly in the forthcoming years, and
obesity ...
HMBG1 and other soluble factors in HIV-1 pathogenesis
(2009-01-30)
The innate immune system is the first defense mechanism invading
pathogens encounter. Macrophages, dendritic cells and
cytokines/chemokines are important factors for the functionality of the
innate immunity, and provide ...
Brain volume reduction over four decades in multiple sclerosis
(2010-05-07)
Introduction: Multiple sclerosis (MS) is a common neurological disease causing intermittent or cumulative disability, predominantly among women of child-bearing age. MS is a chronic inflammatory disease of the central ...
Muscle mass and function after total hip arthroplasty
(2009-04-17)
muscles recovered fully. There was still a reduction in CSA for m. iliopsoas (7.0 %) and hip adductors (8.4 %) and in RD for mm. gluteus maximus (10.1 HU), gluteus medius/minimus (5.6 HU), iliopsoas (3.9 HU) and adductors (2.4 HU). Limp was recovered...