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Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
convalescent samples (<6 weeks), complemented by late convalescent samples (>5 years) from 20 patients, previously serotyped by PCR were included in the study. The correct serotype was determined in 80% (16/20) of the late convalescent samples, while...
Teleost retina : a model to study neurogenesis and angiogenesis
(2009-03-09)
Teleost models, zebrafish and medaka have become popular models to study
various aspects of developmental biology and genetics. The rapid
embryonic development, transparent embryos and the availability of many
mutants ...
Components controlling vesicle trafficking and regulated exocytosis in pancreatic beta-cells
(2009-11-11)
-cells, and that Cdk5, activated by the p39 subunit, augments Ca2+-induced insulin exocytosis. Moreover, we show that Cdk5/p39 acts, at least partly, by phosphorylation of Munc18-1, a member of the SM protein family. To explore the potential presence of additional Cdk5...
Drug-related problems with special emphasis on drug : drug interactions
(2009-09-04)
-patients and to determine whether a pharmacotherapeutic advisory intervention aiming at reducing DRPs could affect rates of re-hospitalisation and / or death within 6 months. A total of 299 DRPs among 71% (106/150) of the patients were found, who had not previously been...
Prevention of mother-to-child transmission of HIV-1 using antiretroviral drugs in Dar Es Salaam, Tanzania
(2009-08-21)
and the relative risks (RR) for transmission in the treatment groups compared to placebo were 0.37, 0.58 and 0.93 respectively. The combined HIV-1 infection or death rates at 6 weeks were 7.0%, 11.6%, 17.5% and 18.1% in groups A, B, C, and the placebo group...
Molecular characterization of Mycobacterium tuberculosis complex isolates from Sweden
(2010-04-21)
Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex
(MTC), is a serious infection in man and animals. According to the World
Health Organisation (WHO), about one third of the world´s population is
infected ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
the atrophy factors that contributed most significantly to the diagnoses with correct AD classification of 90.2%. The correct classification of AD+CVC from controls increased from 79.5% (only CSF biomarkers) to 84.6% (combined CT measurements with CSF...
Genetic content of clinical pneumococcal isolates and its relation to disease outcome
(2009-09-30)
carriage or invasiveness. No obvious candidate was found. ARs 6 and 34 were found in most of the invasive isolates and were absent in most of the isolates of low invasive disease potential and were tested for invasiveness in a mouse model of infection. We...
Mass spectrometric investigation of intoxications with plant-derived psychoactive substances
(2009-05-08)
The flora of the world contains many plants and fungi with stimulant, hallucinogenic and narcotic effects. For centuries, many of these have been used in initiation rites, physical and spiritual healing and rites of ...
Ultrastructural studies of the blood-urine barrier in proteinuric states
(2010-04-30)
The kidneys filter enormous amounts of blood every day, removing excess fluid and waste products while retaining cells and large proteins in the circulation. The podocytes with their foot processes and slit diaphragms (SD) ...