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Smärta, infektion och återanpassning till livet efter en brännskada
(2010-01-22)
A burn injury is an unforeseen event that includes a physical as well as
a psychological trauma for the person afflicted. The trauma is
experienced differently by individuals as do perceived problems during
care, ...
Isoforms of mammalian glutaredoxin 2
(2009-05-05)
lies upon the question how Grx2 activity is regulated as well as how many isoforms of mammalian glutaredoxin 2 there are. Here, we have characterized human Grx2 as the first iron sulfur centercontaining thiol-disulfide oxidoreductase of the thioredoxin...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
dihydropyrazolone, namely 4-cyano-1-cyanoacetyl-2-(cyclohexen-1-yl)-1,2-diazaspiro[4.5]decan-3-one, whose structure was confirmed by an X-ray analysis. Mild hydrolysis of this compound resulted in isolation of a des-cyanoacetylated product. In addition, prolonged...
Optimisation of dengue diagnostic tools in order to increase the knowledge of the pathogenesis
(2008-10-03)
and by dengue IgM ELISA. Only samples collected until day 5 post onset were found positive by PCR: in 73% (35/48) of the samples, dengue RNA of serotypes 1, 2 or 3 was detected. The number of genomes/ml varied between 103 and 108, with a gradual decline over...
In vivo functions of mammalian glutaredoxin 2
(2008-08-29)
inactive. Monomerization induced by both oxidants and reductants activated the protein. Based on these findings, we have proposed a role as redox-sensor for the cluster: under normal conditions the majority of Grx2 in the cell is present in the inactive...
CYP2C-dependent drug metabolism in vivo : influence of genetics and drug interactions
(2010-11-24)
Cytochrome P450 enzymes (CYPs) are responsible for the metabolism of the majority of therapeutic drugs. This thesis focuses on one of the CYP subfamilies, CYP2C, especially CYP2C9 and CYP2C19, which are responsible for the metabolism of 15– 20...
Genetic, epigenetic and environmental factors of importance for CYP1A2 catalyzed drug metabolism
(2008-11-14)
The heme containing cytochrome P450 (CYP450) enzymes participate in the phase I metabolism of drugs and other xenobiotics as well as endogenous substrates. CYP1A2 is one of the major CYP450 enzymes and account for about 13% of the total CYP450...
Integrin-interacting proteins in human cancer progression
(2010-04-02)
appealing targets for cancer therapy. Kindlin and PAK (p21-activated kinase) family proteins have been identified as integrin-interacting proteins. The following studies in this thesis aimed to investigate the role of Kindlin-2 and PAK5 in human cancer...
The role of 5'-nucleotidases and deoxynucleoside kinases in responses to nucleoside analogues
(2010-04-30)
The efficacy of nucleoside analogues (NAs) in treating several
hematological malignancies, solid tumors and viral infections is limited
primarily by side-effects and the development of drug resistance. The
aims of the ...
Effects of Alzheimer's and Parkinson's disease gene mutation on cell signaling
(2009-01-09)
Alzheimer's disease (AD) and Parkinson's disease (PD) are the major
neurodegenerative disorders affecting the elderly. The discovery of genes
causing familial forms of these disorders has contributed enormously
towards ...