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Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
This thesis will mainly focus on the chemistry of nitrogen containing heterocyclic compounds, particularly pyrazole and benzotriazine and related ring systems to these compounds. The first part includes a short introduction ...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
′-dithiobisindoles is described. In addition, the heterocyclic core of the marine alkaloid echinosulfone A, namely 3,3′-bis(indolyl) sulfone, was obtained by treatment of a 3-lithioindole derivative with bis(phenylsulfonyl) sulfide. These methodologies offer...
Polycyclic aromatic hydrocarbons : DNA damage and cell signaling
(2008-11-28)
Oxidative stress is a threat to our wellbeing. The formation of reactive
oxygen species may result in oxidative lesions in DNA and RNA. When
challenging A549 cells with 18O-labeled hydrogen peroxide, we found that
RNA ...
Intramuscular or periosteal acupuncture for patients with chronic musculoskeletal pain in the neck and low back : effects on pain, physical and psychological functioning
(2008-10-23)
Background: Periosteal acupuncture has shown promising results in the
clinic. No studies of effects in patients with chronic pain in the neck
and low back are today available.
Aims: The main purpose was to compare ...
Leukocyte activation in newborns in relation to prenatal stress
(2009-11-05)
3 times higher compared to C-section indicating fetal peptide release. Neutrophils from cord blood after normal delivery contain 10 times more cytoplasmatic cathelicidin peptide compared to corresponding cells after C-section where a strict granular...
Recessive parkinsonism, mitochondria and translational regulation
(2008-09-05)
Three genes are known to cause recessive forms of Parkinson disease (PD) in humans: parkin, PINK1 and DJ-1. Of these, the rarest is DJ-1; less than fifty known cases worldwide are due to mutations in DJ-1. Though rare, ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
) together with CSF biomarkers is suggested to be the most important diagnostic markers for AD, it may not be specific. The current method of choice to measure MTA has been volumetric measurement based on 3D magnetic resonance imaging (MRI...
Influence of renal dysfunction on therapy and prognosis in patients with myocardial infarction
(2010-04-30)
The aim of this thesis is to evaluate the influence of renal dysfunction on the presentation for myocardial infarction (MI), its treatment and outcome. Patients between 2003 and 2006 were selected from the nationwide Swedish ...
Genetic and epidemiological studies of dystocia : difficult labour
(2008-12-19)
Objective: To explore the epidemiological characteristics, the influence
on reproductive health and the genetic basis of dystocia prolonged and
difficult labour.
Material and methods: The thesis has a retrospective ...