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CD8alpha/alpha+ T-cells and immune memory
(2009-04-29)
A better understanding of T-cell memory formation is crucial for rationale vaccine design and the identification of correlates of immune protection. The CD8αα homodimer expressed on CD8+ T-cells is not anymore considered to represent a TCR co...
Brain mechanisms in pain regulation
(2009-10-02)
on the function of the noradrenergic and dopaminergic systems, is related to the response dynamics of repeated pain stimulations following opioid administration. Results suggest that the initial pain response is not influenced by the COMTval158met polymorphism...
Tobacco smoking, high body mass index and the outcome after surgery : the role of intervention
(2008-11-07)
The negative effects of smoking and obesity on public health are
well-known. Despite this knowledge, the smoking-attributable morbidity
and mortality is estimated to rise rapidly in the forthcoming years, and
obesity ...
Drug treatment in children with focus on off-label drug use
(2010-08-06)
There is a lack of paediatric documentation concerning efficacy and
safety of many drugs, which contribute to drug use outside the terms of the product license (off-label). In the present thesis, four studies (I-IV), using ...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
This thesis will mainly focus on the chemistry of nitrogen containing heterocyclic compounds, particularly pyrazole and benzotriazine and related ring systems to these compounds. The first part includes a short introduction ...
The Rarebit fovea test : a new measure of visual function
(2008-04-23)
Visual acuity (VA) measurement by the use of letter charts is the most
frequently used method for testing foveal function. However, since a
decimal visual acuity of 1.0, often used as limit for normality, can be
achieved ...
Injury profile and injury risk factors in junior tennis players
(2010-05-28)
The aim of the present investigation was to prospectively study injuries sustained by a cohort of junior players at all levels in a typical tennis club with respect to gender, anatomic location of injuries, type of injuries, ...
Kaposi's sarcoma and malignant lymphomas in Tanzania during the AIDS epidemic
(2009-02-27)
Kaposi s sarcoma (KS) studies Kaposi´s sarcoma (KS) is the most frequent AIDS tumor (AKS) and associated with HHV-8, but controversial whether a clonal tumor or mostly a reactive proliferation of endothelial spindle cells (SC). In the present...
Studies on hereditary spastic paraplegia proteins
(2010-05-14)
The hereditary spastic paraplegias (HSPs) are a clinically and genetically diverse group of inherited neurological disorders that primarily cause progressive spasticity and weakness in the lower limbs due to a length-dependent, ...
Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients
(2010-03-26)
higher mRNA expression of hepatic ABCG5, ABCG8 and LXRalpha, which correlated with biliary cholesterol molar percentage and cholesterol saturation index (CSI). The mRNA and protein levels of the hepatic scavenger receptor B type I (SRBI) were increased...