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Sexual life after childbirth and aspects of midwives’ counselling at the postnatal check-up
(2009-02-27)
The overall aim of this thesis was to explore and describe how sexual
life after childbirth is communicated, addressed and reflected upon among
new mothers, fathers and midwives and the impact of leaving first and
minor ...
The role of CYP3A4/5 in alprazolam metabolism
(2010-05-14)
Cytochrome P450 3A (CYP3A) enzyme family is involved in the metabolism of about 50 % of all drugs in clinical use. Among CYP3A, CYP3A4 and CYP3A5 are the major enzymes in adults; however CYP3A5 is polymorphic and primarily expressed in black...
Application of metalation reactions for synthesis of sulfur/selenium-containing heterocyclic compounds
(2009-09-25)
′-dithiobisindoles is described. In addition, the heterocyclic core of the marine alkaloid echinosulfone A, namely 3,3′-bis(indolyl) sulfone, was obtained by treatment of a 3-lithioindole derivative with bis(phenylsulfonyl) sulfide. These methodologies offer...
Synthetic studies of nitrogen containing heterocycles, particularly pyrazole and benzotriazine derivatives
(2009-11-06)
This thesis will mainly focus on the chemistry of nitrogen containing heterocyclic compounds, particularly pyrazole and benzotriazine and related ring systems to these compounds. The first part includes a short introduction ...
Gene regulation mechanisms by the transcriptional coregulator mastermind-like 1
(2009-03-27)
and with histones, and that the p300-MAML1 complex specifically acetylates the tails of histones H3 and H4. Furthermore, we showed that MAML1 is acetylated by p300, and identified conserved lysines in the MAML1 N-terminus as the target for p300 acetylation. We found...
Wnt signaling affects cell adhesion and neuronal differentiation
(2008-05-23)
The mammalian central nervous system (CNS) consists of the brain and the spinal cord. The entire CNS is derived from the walls of a fluid-filled neural tube that is formed at an early stage of embryonic development. The ...
Nervous mechanisms of postural control
(2009-05-14)
Maintenance of body confguration and orientation in space (postural control) is a vital motor function. A general goal of the present study was to analyze nervous feedback mechanisms for the maintenance of posture during ...
Intramuscular or periosteal acupuncture for patients with chronic musculoskeletal pain in the neck and low back : effects on pain, physical and psychological functioning
(2008-10-23)
Background: Periosteal acupuncture has shown promising results in the
clinic. No studies of effects in patients with chronic pain in the neck
and low back are today available.
Aims: The main purpose was to compare ...
Studies of histone modification systems in Schizosaccharomyces pombe
(2010-05-26)
150D the reverse transcripts decreased to 25% of wild type levels. In the double mutant dcr1delta/rpb7-G150D the reverse transcript levels remained low indicating that Rpb7 functions upstream of Dcr1 in the RNAi pathway that maintains the H3K9me2...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
) together with CSF biomarkers is suggested to be the most important diagnostic markers for AD, it may not be specific. The current method of choice to measure MTA has been volumetric measurement based on 3D magnetic resonance imaging (MRI...