Karolinska Institutet Open Archive
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Risk factors for colorectal cancer and the impact on life in lynch syndrome
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-23)Colorectal cancer (CRC) constitutes the third most common cancer in Sweden. Approximately 2-4% of CRC cases have a pathogenic variant in a gene known to cause an inherited risk of CRC. The most common hereditary CRC ... -
Developing an embryonic stem cell-based cell product for age-related macular degeneration
(Inst för klinisk vetenskap, intervention och teknik / Dept of Clinical Science, Intervention and Technology, 2024-04-22)Age-related macular degeneration (AMD) remains a major cause of blindness with no current cure. With the increasing ageing population in the developed world, a high number of AMD patients is expected. AMD can be distinguished ... -
Exploring T cell mediated immunotherapy against therapy resistant leukemic stem cells
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-19)The cancer stem cell (CSC) model suggests that cancers depend on continuous replenishment from rare and distinct CSCs, but their existence has been challenging to prove for many malignancies. The CSCs in myeloid ... -
Navigating the oligodendroglial chromatin landscape using high-throughput single-cell epigenomics
(Inst för medicinsk biokemi och biofysik / Dept of Medical Biochemistry and Biophysics, 2024-04-19)The central nervous system (CNS), which includes the brain and spinal cord, is a remarkably complex system composed of billions of cells controlling everything ranging from basic metabolic functions to higher executive ... -
Exploring lipoprotein characteristics in human cardiometabolic disease
(Inst för medicin, Huddinge / Dept of Medicine, Huddinge, 2024-04-18)Background: Atherosclerosis underlies most cases of cardiovascular disease (CVD) which remains the principal cause of global mortality. CVD is significantly linked to cardiometabolic diseases such as diabetes and obesity. ...