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Elbow kinematics : studies of the elbow joint under normal conditions and after joint replacement
(2010-05-28)
Background: Total elbow arthroplasty (TEA) is used for treatment of
patients with severe pain and disability due to reumatoid arthritis. Long
term results are not as good as for hip and knee replacements. Further
development ...
On histone deacetylases in the epigenetic regulation of neural stem and cancer cell fate
(2008-05-15)
histone proteins H2A, H2B, H3, H4, and 146 base pairs of DNA, wrapped around the histones. In this way, DNA can be tightly packaged in the cell. The N-terminal tails, that protrude out from the histone surfaces can be subjected to different covalent...
Functional gastrointestinal disorders : co-morbidity and non-somatic aspects
(2008-05-19)
Aims of the thesis: The first aim, (Study I) of this thesis was to
compare co-morbidity of the reported symptoms and its relation to
healthcare seeking behaviour among non-patients who had persistent
functional ...
Brain MRI and CT morphology in healthy aging and Alzheimer's disease
(2010-02-05)
Background: The brain atrophy in individual Alzheimer's disease (AD) patients includes not only specific atrophy from AD pathology, but also atrophy induced by normal aging and cerebral vascular diseases. Although medial ...
Tissue biomarkers in prostate cancer
(2009-09-25)
Prostate cancer (PC) is the most common male cancer in the western world. Better biomarkers are needed to support diagnosis, prediction of prognosis and treatment decision Radical prostatectomy (RP) specimens are routinely ...
Studies on female genital tract infections and the role of nitric oxide in diagnosis
(2010-04-16)
Female genital tract infections are among the most common conditions causing individuals to seek medical care, and are associated with a high gynaecologic and reproductive morbidity. Thus, prompt and precise diagnosis of ...
Mutations and molecular signatures in human melanoma
(2010-02-05)
. With this work, we wanted to obtain further insights into the biological background of skin melanoma in different stages of progression. We focused on commonly altered pathways and genes, NRAS, BRAF and CDKN2A, and their effects on activation and expression...
Impact of candidate genes on obesity and type 2 diabetes
(2011-03-11)
Obesity and type 2 diabetes (T2D) have strong genetic components. Identification of susceptibility genes in both diseases will give better knowledge of their pathomechanisms and future therapies. In this thesis, the candidate gene approach was used...
Acute myocardial infarction and glucose abnormalities : novel risk markers and characteristics
(2009-01-23)
as regards their beta-cell function (Study I); 2. To investigate the long-term reliability of the early classification of glucose perturbations by means of an oral glucose tolerance test (OGTT) in patients with AMI without previously known glucose...
Aprotinin for reduction of bleeding and transfusions in patients on clopidogrel undergoing urgent coronary surgery
(2009-05-08)
-860) in the aprotinin group vs. 1210 mL (95%CI:860-1550) in the control group (p=0.004). The aprotinin group received fewer transfusions of packed red blood cells (0.9 U, 95%CI:0.1-1.7, vs. 2.7 U, 95% CI:1.4-4.1; p=0.01), platelets (0.1 U, 95%CI:0-0.3, vs. 0.6 U, 0.2- 0...