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Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
The impact of airway-irritating exposure and wet work on subjects with allergy or other sensitivity : epidemiology and mechanisms
(2007-09-14)
The prevalence of asthma and allergies is increasing, which means that
the proportion of workers on the labour market with allergy or other
sensitivity also increases. It is as of yet not known to what extent
these ...
Molecular mechanisms of estrogen action in relation to metabolic disease
(2007-11-16)
Estrogens have multiple effects on the body. Most studied are the
effects on female reproduction. In this thesis, we have focused on the
metabolic effects of estrogens. Estrogen treatment decreases adipose
tissue mass ...
Parental smoking, wheezing and sensitisation in early childhood
(2008-01-18)
years of age the response rate was 91% (3,619 children) and among these 73% participated in a clinical investigation including peak flow measurements and blood sampling for analyses of IgE antibodies to common inhalant and food allergens. Odds ratios...
Role of estrogen receptor beta in mouse prostate and bladder with references to human diseases
(2007-11-15)
After the discovery of estrogen receptor beta (ERbeta) in 1995, it
became clear that in many non-classical estrogen-responsive organs,
were in fact direct targets for estrogen. One of these organs is prostate
gland, ...
GDNF and its receptors : a structure-function analysis of the NCAM-GDNF-GFRalpha1 complex and an examination of potential receptor candidates
(2008-05-01)
Neurotrophic factors are small, secreted proteins that are important
players in the development and maintenance of the nervous system. Their
functions span from neuronal survival and migration to neurite outgrowth
and ...
Long-term tracheostomy : outcome, cannula care, and material wear
(2007-09-21)
Do people with long-term tracheostomy need hospital care? Which cleaning
method is most appropriate for decontamination of inner cannulae? Are
tracheostomy tubes changed for rational reasons? There is clearly a lack
of ...
Molecular mechanisms of AhR mediated endocrine disruption of estrogen and retinoic acid signalling pathways
(2008-02-01)
Dioxins and similar compounds are toxic substances ubiquitously present in the environment. The most potent dioxin, 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), is considered to be one of the most toxic compounds known to man. Dioxins have been shown...