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Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
Gliomas are the most common glial neoplasms, accounting for nearly 70% of
all primary brain tumours. The progression of low-grade gliomas into more
aggressive tumours is supported by the abnormal function of several
prot ...
Molecular mechanisms of estrogen action in relation to metabolic disease
(2007-11-16)
Estrogens have multiple effects on the body. Most studied are the
effects on female reproduction. In this thesis, we have focused on the
metabolic effects of estrogens. Estrogen treatment decreases adipose
tissue mass ...
The impact of airway-irritating exposure and wet work on subjects with allergy or other sensitivity : epidemiology and mechanisms
(2007-09-14)
The prevalence of asthma and allergies is increasing, which means that
the proportion of workers on the labour market with allergy or other
sensitivity also increases. It is as of yet not known to what extent
these ...
Analgetic and algetic effects of adenosine in healthy volunteers and patients with coronary disease
(2007-11-23)
Background: Adenosine is a bimodal neuromodulator with algesic and analgesic effects. The different effects of adenosine are partly due to the route of administration. Low-dose adenosine infusion induces analgesia at the ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Exosomes in immune regulation and allergy
(2007-04-20)
Exosomes are nano-sized vesicles of endosomal origin which are secreted from several different cell types. Depending on their cellular source they have been suggested to have different functions, like having a role in ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...
Esophageal cancer surgery : factors influencing survival
(2007-01-19)
The principal aim of this thesis was to address factors that may affect
survival after esophageal cancer surgery. Surgical resection remains the
only established potentially curative treatment for patients with
resectable ...
Rheumatoid arthritis as a modifier of periodontitis
(2007-01-19)
Periodontitis is a chronic tissue-destructive condition in which the
tooth-supporting collagen fibers of ligament and bone are broken down
mainly by the host s overreactive immune inflammatory response. The
relation between ...