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Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility ...
Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation
(2008-03-07)
Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed ...
Charcterization of biotransformation systems in human cells
(2007-05-25)
in the protection of DNA. A novel immunocytochemical method for visualization of subcellular compartmentalization of GSH was described. Confocal microscopy of stained A549 cells showed that the GSH levels of the nuclear and cytosolic compartments are close...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Mdm2 phosphorylations : characterization and applications
(2007-09-07)
Cancer is a widespread disease. In spite of all research resulting in new
improved therapies, there are still many tumors that cannot be cured. To
oppose that, also a preventive research approach is important with ...
Menstrual status and long-term cardiovascular effects of intense exercise in top elite athlete women
(2008-03-28)
Although physical exercise is generally beneficial for health, female athletes run an elevated risk of developing chronic energy deficiency, with ensuing severe consequences such as reproductive dysfunction, bone ...
Hypnosis monitoring during general anaesthesia : with focus on awareness
(2007-11-09)
An objective measure of the hypnotic component of general anaesthesia
has been sought for decades. The electroencephalogram (EEG) was early recognized as a possible useful
intraoperative monitor when the effects of ...
Effects of endurance exercise on mitochondrial efficiency, uncoupling and lipid oxidation in human skeletal muscle
(2006-12-29)
During the lest years the importance of muscle mitochondria, and mitochondrial function, not only for performance but else for health has been highlighted. The main function of the mitochondria is to produce ATP by oxidative ...
Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Novel extrahepatic P450 enzymes with emphasis on the tumor specific CYP2W1
(2007-04-05)
. The expression of P450s in tumors has drawn
interest because their presence might influence cancer therapy and since
the enzymes may be utilized as drug targets in new cancer therapy
strategies. In the current study two novel extrahepatic P450s, CYP2U1 and
CYP2W1...