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Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
About 30,000 people in Sweden are affected by stroke each year. The
effect on physical functioning, and also consequences such as depression
and aphasia, are likely to affect not only the life of the patient, but
also the ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Observing the darkest matter of the genome : expression of human endogenous retrovirus W elements
(2008-05-09)
The human genome is composed of coding genes and vast stretches of
sequences largely considered junk. Researchers are, however, uncovering
widespread and extensive transcription of not only the coding, but also
of the ...
Two novel combination therapies of glioblastoma multiforme from a Cx43 perspective : studies of in vitro models
(2008-03-28)
The group of patients suffering from the malignant brain tumour
glioblastoma multiforme (GBM) have a median survival of only about one
year. Thus, new treatment strategies are urgently needed.
Gap junctions are ...
Pregnancy rhinitis : pathophysiological effects of oestrogen and treatment with oral decongestants
(2007-10-19)
Pregnancy rhinitis, a common condition, is thought to affect about 20 %
of pregnant women. This type of rhinitis may develop at any time during
pregnancy and the nasal stuffiness usually disappears shortly after
delivery. ...
Charcterization of biotransformation systems in human cells
(2007-05-25)
-related genes, such as UDP-glucuronosyltransferases (UGTs), drug transporters and transcription factors were also studied using low density arrays. The mRNAs for a variety of CYPs and liver-related factors as well as CYP1A2 and CYP3A4/7 protein were shown...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility ...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due ...