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Functional genomics studies of PINK1
(2007-10-25)
established a human in vivo model for mitochondrial dysfunction. Microarray analyses of the same sample-set suggested that PINK1, a novel mitochondrial kinase, was down regulated during inactivity. PINK1 is transcribed from a complex locus, alternatively...
Transcriptional and post-transcriptional regulation of telomerase reverse transcriptase (hTERT) expression : the role of histone modification and alternative splicing
(2008-01-18)
Telomerase, an RNA-dependent DNA polymerase responsible for telomeric DNA
elongation, is silent in most normal differentiated human cells due to
the tight repression of its catalytic unit, telomerase reverse
transcriptase ...
Liquid chromatography : mass spectrometry study of two biochemical alcohol markers
(2007-03-09)
The interest in biochemical alcohol markers for detecting acute and
chronic alcohol consumption has expanded greatly during recent years. The
development and application of laboratory tests identifying early
problematic ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Cataract induced by UVR-B 300nm : characterization and genetic modulation of the lens sensitivity to oxidative stress
(2008-03-28)
Cataract is defined as an opacification of the lens resulting in visual
impairment. Worldwide, it is the number one cause of blindness and there
are currently no strategies to prevent the onset of the disease. Cataract
surgery ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Low back pain among industrial workers : occupational health studies on prevalence, incidence, and associations with work and lifestyle in I.R. Iran
(2007-02-23)
This thesis presents the results from a prospective industrial population
cohort study on epidemiology and risk factors for low back pain (LBP) in
Iran. The four papers in the thesis were based on a cross-sectional
survey ...
Placebo, alcohol and flumazenil provocations : subjective and objective registrations in psychopharmacological experiments
(2007-01-12)
Abuse and dependency of alcohol or drugs is a major problem today, with
severe implications for society as well as for the individual. Treatment
is often characterised by hard work and the road to recovery is (among
other ...
Changes in human uterine innervation in term pregnancy and labor occurence and roles of neurotrophins and TRPV1
(2008-03-14)
Objective: Cervical ripening, is a prerequisite for successful labor,
which is often very painful and involves an inflammatory reaction.
However, little is presently known con-cerning nerve-related changes in
the human ...
The N-methyl-D-aspartate receptor subunit NR3A : cloning, expression and interacting proteins
(2008-03-28)
This thesis focuses on the subunit NR3A, which together with subunits NR1, NR2A-NR2D and NR3B builds the excitatory glutamate receptor N-methyl-D-aspartate (NMDA). The receptor is most likely a tetramer, containing at least one NR1, probably two NR2...