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Passive volume reduction heart surgery using the Acorn CorCap cardiac support device
(2007-09-14)
Heart failure is a growing health problem, affecting an increasing number
of patients with rapidly increasing costs for the health care system. In
spite of recent improvements in pharmacological, non-pharmacological ...
Studies on natural antisense RNAs and microRNAs
(2007-11-27)
Regulatory RNAs are found in all kingdoms of life and involved in
regulation of gene expression at various steps including RNA splicing,
editing, stability, modification, export, translation and chromatin
remodelling. ...
Strategies to increase effectiveness of growth factor receptors-targeted therapy in glioblastoma
(2007-11-14)
factor receptor tyrosine kinases
(GFR-TKs). In paper I, we showed that the pharmacologic inhibition (using
small molecule inhibitors) of IGF-1R, PDGFR and their intracellular
signalling via PI3-K and ERK1/2 kinases had only modest or not antitumour...
Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects
(2008-04-04)
Oxaliplatin is a platinum-based cytostatic drug. It is used in
combination with 5-fluorouracil and leucovorin for palliative and
adjuvant treatment of metastatic colorectal cancer. The biotransformation
of oxaliplatin ...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
Autocrine/paracrine interactions moendocrine pancreasdulating hormone release in the endocrine pancreas
(2007-11-07)
machine with high throughput capabilities which integrates with other commercial high content screening systems. These technologies were successfully applied to measure [Ca2+]i and hormone release from batches of damaged islets with decreased viability...
Effects pf hypoxia and antiepileptic drugs of electrophysiological properties of CA1 neurons in hippocampus
(2007-05-25)
This thesis is based on three experimental studies (I-III) of CA1 hippocampal neurons in rat brain slices, where the electrophysiological properties are examined with patch clamp technique under hypoxic conditions and ...
Analysis of neuropathic pain after spinal cord injury
(2008-01-18)
Longstanding neuropathic pain is a challenge in spinal cord injury (SCI) rehabilitation. Once established it is difficult to treat successfully. Neuropathic pain has a negative influence on quality of life and on the outcome ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...