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Molecular dynamics simulations of RNA bulges, loops and base flipping
(2008-01-11)
out at pH 5.7. The pathway of this base flipping is studied. We demonstrate that the minor groove pathway is preferred over the major groove pathway, and that protonation on an A adjacent to the flipping U lowers the energy barrier ~3.5 kcal...
Physical activity in the severely obese : studies on measurement and promotion
(2007-03-26)
Background: The amount and quality of evidence on how to effectively
promote physical activity (PA) is low compared to what is known about the
health effects of regular PA, especially in obese individuals.
Aim : ...
Psychological health and life situation in spouses of stroke patients
(2007-05-25)
participating in a support- and
education programme had significantly more knowledge about stroke after
12 months compared to the controls. No difference in psychological health
was found. However, the 5 participants appreciated the group sessions...
Clinical studies of biomarkers in suicide prediction
(2007-10-19)
of two biomarkers: the nonsuppression in the dexamethasone suppression test (DST) and low 5-hydroxyindoleacetic acid (5-HIAA) in the cerebrospinal fluid(CSF) in suicide prediction in clinical high-risk groups and to investigate relationships of the two...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Studies of ischemia and reperfusion in muscle and liver on glutathione and amino acid metabolism in man
(2007-11-23)
surgery. In
this study biopsies were obtained before ischemia, at maximal ischemia
and at 5, 10, 15, 20, 25 and 30 minutes of reperfusion.
Results from the first two studies show that both reduced and total
glutathione are decreased at 24 and 48 hours...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
. coli resistance to ciprofloxacin increased from 0% in 1991 to 11% in 1999 and co-trimoxazole resistance increased in E. coli from 7.5% to 14% during the study period. For E. coli, resistance to ciprofloxacin was higher at the hospital than at the ICUs...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility ...
On the role of different signal transduction pathways in induction of apoptosis by anticancer drugs
(2007-04-13)
Anticancer drug treatment gives rise to complex cellular responses in
tumor cells. An improved understanding of the mechanisms underlying these
responses is important in order to improve treatment. It is also of
importance ...