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Regulation and characterization of antimicrobial peptides in man and mice
(2007-09-07)
The gene-encoded antimicrobial peptides have emerged as an important
component of innate immunity. In mammals, antimicrobial peptides are
either directly secreted from cells or found in cell granules, which can
be ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Studies of ischemia and reperfusion in muscle and liver on glutathione and amino acid metabolism in man
(2007-11-23)
ischemia, at maximal ischemia and after 10 min, 4, 24 and 48 hours
of reperfusion. In a second study aorto bi-femoral surgery patients were
studied because of the longer ischemia times up to 120 minutes with this
procedure. Biopsies from both legs were...
Mast cell activation in response to osmotic and immunological stimulation with focus on release of eicosanoid mediators
(2007-03-02)
was found to induce the release of PGD2 and
LTC4 in CBMC in vitro. Prostaglandin D2 was formed both via the COX-1 and
COX-2 pathways in CBMC. The late response after stimulation with the
combination of anti- IgE and IL-1beta was more COX-2 dependent. Further...
Studies of immunopathogenic mechanisms and treatment of chronic, inflammatory myopathies, myositis
(2007-10-12)
Polymyosit (PM), dermatomyositis (DM) and sporadic inclusion body
myositis (sIBM) are chronic inflammatory myopathies which are
characterized by muscle weakness, fatigue and extra-muscular involvement.
Mononuclear ...
Renal insufficiency, mortality and myocardial infarction
(2008-05-09)
for the highest versus the lowest quartile of the apoB/apoA-1 ratio was 2.88 (2.54 to 3.26) compared to HR, 3.35 (2.25 to 4.91) for those with CKD. After adjustment for the total cholesterol/ high-density lipoprotein cholesterol ratio, an increase by one standard...
Nephrin : intracellular trafficking and podocyte maturation
(2007-11-23)
Congenital nephrotic syndrome of the Finnish type, CNF, is an autossomal
recessive disorder caused by mutations in the NPHS1 gene and,
consequently, in its product nephrin, a 180 kDa transmembrane protein
belonging to ...
Effects pf hypoxia and antiepileptic drugs of electrophysiological properties of CA1 neurons in hippocampus
(2007-05-25)
This thesis is based on three experimental studies (I-III) of CA1 hippocampal neurons in rat brain slices, where the electrophysiological properties are examined with patch clamp technique under hypoxic conditions and ...
Exosomes in immune regulation and allergy
(2007-04-20)
showed a higher number of Foxp3+CD4+CD25+ T regulatory cells. Our results show that human breast milk contains exosomes with the capacity to influence immune responses, and this suggests that they might influence the development of the infant immune...