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The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression
(2007-05-17)
A key role of the p53 protein in tumor suppression is reflected by its
frequent mutations in human tumors. p53 is activated by various types
stress conditions such as DNA damage, hypoxia and oncogene activation
that ...
B-cell survival factors in multiple sclerosis and myasthenia gravis
(2007-03-14)
Multiple sclerosis (MS) is a chronic, progressive neurological disease in which death of myelin-producing oligodendrocytes and axonal damage are prominent pathological features. The cause of MS is unknown but genetic and ...
Autocrine and paracrine regulation of Leydig cell survival in the postnatal testis
(2007-09-07)
The primary function of testicular Leydig cells is the production of androgens that promote sexual differentiation in the fetus, secondary sexual maturation at the. time of puberty, and spermatogenesis in the adult. ...
Analysis of different forms of locomotor behavior in lamprey
(2007-05-25)
The ability to locomote, that is move actively in space, is characteristic of the animal kingdom. Many species are capable of different forms of locomotion. They include forward and backward locomotion, fast and slow ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Cardiorespiratory fitness and cardiovascular disease risk factors in children and adolescents
(2007-03-09)
Cardiovascular disease (CVD) events occur most frequently during or after the fifth decade of life, however, there is evidence indicating that the precursors of CVD has its origin already in the first or second decade of ...
Alcohol and inflammation : a study of effects of ethanol on endothelial and epithelial cell functions
(2007-10-26)
Although short–term alcohol drinking causes euphoric and stress relieving effects, alcohol abuse is a major risk factor for neurobehavioural, liver and muscle injury as well as reduced host defence with enhanced susceptibility ...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Aspects of the role of mineral oil as immunological adjuvants in rheumatoid arthritis
(2007-02-16)
Environmental factors are likely contributing factors in the development of Rheumatoid Arthritis (RA), an autoimmune disease, for which etiologic factors are still poorly known. Mineral oils are efficient adjuvants which ...
Rheumatoid arthritis as a modifier of periodontitis
(2007-01-19)
Periodontitis is a chronic tissue-destructive condition in which the
tooth-supporting collagen fibers of ligament and bone are broken down
mainly by the host s overreactive immune inflammatory response. The
relation between ...