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Analytical and pharmacological studies of cyclophosphamide
(2008-03-17)
-liquid extraction (LLE) and analyzed using liquid chromatography with UV detection (LC-UV). The limit of detection (LOD) was 0.005 μg/mL and the limit of quantification was 0.5 μg/mL for LC-MS/MS. The accuracy of the quality control (QC) samples ranged from 91...
Tonsillar cancer : incidence, prevalence of HPV and survival
(2008-04-04)
Since human papilloma virus (HPV) in the mid 1980ies was first observed
in squamous cell carcinoma of the head and neck, its role and impact,
especially on oral and oropharyngeal cancer, have attracted extensive
interest. ...
Antibiotic resistance and antibiotic consumption with focus on Escherichia coli and Pseudomonas aeruginosa
(2007-05-04)
. coli resistance to ciprofloxacin increased from 0% in 1991 to 11% in 1999 and co-trimoxazole resistance increased in E. coli from 7.5% to 14% during the study period. For E. coli, resistance to ciprofloxacin was higher at the hospital than at the ICUs...
Microfluidic electrocapture in proteomic sample preparation for mass spectrometry
(2007-10-19)
Proteomics is a technology-driven discipline and very labor-intensive.
Over the last couple of years, methods with microfluidic systems have
been used to simplify analytical procedures via integration of laboratory
processes ...
PET evaluation of central serotonergic neurotransmission in women
(2008-02-08)
The serotonin (5-HT) system is of central interest in the patophysiology and treatment of several psychiatric disorders including depression, anxiety and suicide. In women, functioning of the 5-HT system is of particular importance since they have...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Icodextrin metabolism in peritoneal dialysis : clinical and experimental studies
(2007-10-19)
Icodextrin is a glucose polymer which is used as osmotic agent to provide
sustained ultrafiltration (UF) during the long (8-16 hours) dwell in
end-stage renal disease patients undergoing peritoneal dialysis (PD). The
aims ...
Toxicological studies of opiate-related death
(2007-04-25)
This thesis comprises studies on opiate overdose death, and focuses on
evaluation of toxicological characteristics including the possible
influence of abstinence and polydrug use for the fatal outcome.
In order to ...
Serum proteins in type 1 diabetes
(2007-01-05)
We have previously shown that there are patients with type 1 diabetes T1D
whose sera interfere with cytoplasmic free Ca2+-concentration ([Ca2+]i),
resulting in â-cell apoptosis. In this study the frequency of sera, ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...