Search
Now showing items 1-10 of 518
p73 : regulator of differentiation and apoptotic cell death
(2007-05-04)
Neoplasia is characterized by cells' loss of self-control due to
deregulated apoptotic and cell proliferation pathways. Anticancer
treatments aim to induce either cell cycle arrest or apoptosis, and these
effects are ...
In vitro models to study mechanisms of neural cell death induced by toxic agents
(2007-11-29)
of styrene, styrene 7,8-oxide (SO), is
believed to account for most of styrene s toxicity. Carbon monoxide (CO),
an endogenous gas, plays important physiological roles, but CO poisoning
due to accidental or intentional exposure, occurs frequently. CO has...
Gene regulation and immune mechanisms in multiple sclerosis experimental models
(2007-09-04)
Our strategy was to fine map and identify, in an unbiased way, genes or small regions that regulate myelin-oligodendrocyte glycoprotein-induced EAE (MOG-EAE). Such genes are important as they can then be tested for a role ...
On the pro-apoptotic signaling induced by interferon-alpha
(2007-04-06)
Interferon-alpha (IFNalpha) is a pleiotropic cytokine which has been used
as an active drug in the treatment of malignant diseases for almost five
decades. It has shown beneficial results in several hematological
malignancies, ...
Learning across paradigms : towards an understanding of the development of medical teaching practice
(2007-05-12)
The purpose of this thesis was to investigate how educational developers
can work strategically with change to develop quality in higher education
institutions in general and in medical education in particular. The
thesis ...
Weight loss programmes over the internet : opportunities and limitations
(2007-11-21)
Background: Overweight and obesity is increasing in Sweden and over the
world. The societal resources to treat obesity are scarce. Eighty percent
of the population in Sweden have access to a computer and hence the
Internet. ...
Limitations of maximal oxygen uptake during whole-body exercise
(2007-10-26)
Oxygen uptake increases linearly with increased running speed or rate of
work and finally reaches a maximum beyond which no effort can drive it
further. This phenomenon is referred to as the plateau in oxygen
uptake . ...
Regulation of the pro-apoptotic protein Bim by T cell receptor triggering in human T cells
(2006-12-29)
-cells at different stages of their differentiation with particular emphasis on effector CD8+ cytotoxic T-lymphocytes (CTLs). We showed that expression of Bim is upregulated in activated antigen-specific human CTLs upon polyclonal or specific TCR triggering. Both...
Family caregivers of relatives with a life-threatening cancer disease
(2007-05-15)
and development in relational functioning during the first year after the patients diagnosis. In a sample of 91 significant others, data was collected on four occasions. Fifty-two percent of significant others reported change in relational functioning during...
Genomic and transcripto variation in blood stage Plasmodium falciparum
(2007-08-31)
isogenic clones
with distinct adhesive and antigenic phenotypes (rosettes formation for
3D7S8.4 and CD36 binding for 3D7AH 1 S2) were isolated by
micropanipulation. To have a global view of gene expression governing
their phenotypes, we have employed a P...