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Mother and newborn adaptations after birth : influence of administration of oxytocin and epidural analgesia during labour
(2009-08-31)
and prolactin levels rose significantly after 20 minutes. There was a positive correlation between oxytocin and prolactin levels (I). Maternal systolic and diastolic blood pressure fell during the breastfeed by 9 and 8 mmHg, respectively (II). At two days...
β-alanine synthase : one reaction, two folds and mechanisms
(2008-01-11)
beta-alanine synthase (betaAS) is the third enzyme in the reductive
pyrimidine catabolic pathway which is responsible for the breakdown of
pyrimidine bases, including several anti-cancer drugs in higher
organisms. We ...
Joint destruction in rheumatoid arthritis : experimental, clinical and epidemiological studies
(2007-11-23)
Background: Rheumatoid arthritis (RA) is a common autoimmune disease
characterized by chronic polyarticular synovial inflammation. Erosive
joint destruction represents a major unsolved complication of RA.
Objectives: ...
Experimental pharmacodynamic and kinetic studies related to new combination therapies against P. falciparum malaria
(2007-02-09)
Artemisinin (ART) class of compounds are of special interest due to their
rapid onset of action and high activity against multidrug resistant
malaria. The major drawback in monotherapy with ART and its derivatives
is ...
Ultrasound, ions and combined modalities for increased local tumour cell death in radiation therapy
(2007-05-03)
In this thesis, new approaches to improve tumour therapy for patients with inoperable, radiation- and chemoresistant tumours were in focus. Ultrasound and ionising radiation, especially accelerated ions, are both non-invasive ...
Human serum transferrin glycosylation pattern : population differences, analytical methodology and application as a biomarker for testing of alcohol abuse and CDG
(2007-11-16)
Alcohol use and abuse is a major social and economic problem in many
societies. Carbohydrate-deficient transferrin (CDT) is a widely used and
highly specific biochemical alcohol marker of prolonged alcohol abuse.
Increased ...
Colonization, infection and dissemination in intensive care patients
(2007-01-26)
Nosocomial infections are a substantial problem in hospitals all over the world and the incidence is among the highest in the intensive care unit, affecting mortality and morbidity for the individual patient and cost for ...
Hypnosis monitoring during general anaesthesia : with focus on awareness
(2007-11-09)
An objective measure of the hypnotic component of general anaesthesia
has been sought for decades. The electroencephalogram (EEG) was early recognized as a possible useful
intraoperative monitor when the effects of ...
Exposure to skin irritants : validation of questions and epidemiological aspects
(2008-03-14)
Hand eczema is common, and is the most frequent occupational skin disease. Exposure to skin irritants contributes to hand eczema. Common skin irritants are water, detergents, chemicals and foodstuffs. The aim of this thesis ...
Hamstring muscle strain
(2008-04-25)
Background: Acute hamstring strains are common injuries in different sports. They are often serious, causing long rehabilitation times and a proneness for re-injury. Preliminary observations indicate that the injuries can ...