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Mdm2 phosphorylations : characterization and applications
(2007-09-07)
Cancer is a widespread disease. In spite of all research resulting in new
improved therapies, there are still many tumors that cannot be cured. To
oppose that, also a preventive research approach is important with ...
In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5
(2007-11-27)
culture systems were investigated as in vitro
models for tau phosphorylating kinases, with an emphasis on
cyclin-dependent kinase-5 (Cdk5).
In paper I, differentiated SH-SY5Y cell line was investigated as a model
for tau phosphorylation. Sequential...
Glossopharyngeal breathing
(2008-03-21)
Introduction and aims: The technique of glossopharyngeal breathing was introduced already in the 1950 s, but today, few health professionals are aware of its uses. The technique is performed by using the glossopharyngeal ...
Swedish moist snuff and the risk of cardiovascular diseases
(2007-10-19)
The snuff consumption in Sweden has increased substantially during recent
decades and today more than every fifth male adult uses snuff daily.
However, the evidence on health effects from long-term use of snuff is
limited, ...
Biotransformation of the antineoplastic drug oxaliplatin : importance for effects and side effects
(2008-04-04)
Oxaliplatin is a platinum-based cytostatic drug. It is used in
combination with 5-fluorouracil and leucovorin for palliative and
adjuvant treatment of metastatic colorectal cancer. The biotransformation
of oxaliplatin ...
Psychosocial work conditions and musculoskeletal complaint : the role of affective stress response as a mediator of the effect of psychosocial risk factors on musculoskeletal complaints
(2007-11-22)
The hypothesis tested in these two studies was that unfavourable
psychosocial work conditions are expected to increase the risk of
musculoskeletal complaints (MSC), and that this effect is at least partly
mediated by ...
Studies on human sterol 27-hydroxylase with emphasis on its mechanism of regulation and metabolic consequences of a deficient enzyme
(2007-05-11)
Sterol 27-hydroxylase (CYP27A1) is a mitochondrial cytochrome P-450
enzyme present in most animal cells. In hepatocytes, CYP27A1 has an
important role in connection with biosynthesis of bile acids from
cholesterol. In ...
Endothelin receptor antagonism and hypertonic solutions in experimental endotoxin shock
(2007-05-18)
Sepsis is a common and serious condition among patients in the intensive care unit. It is characterized by a systemic inflammatory response, resulting in cardiovascular instability and impaired organ tissue oxygenation due ...
Placebo, alcohol and flumazenil provocations : subjective and objective registrations in psychopharmacological experiments
(2007-01-12)
Abuse and dependency of alcohol or drugs is a major problem today, with
severe implications for society as well as for the individual. Treatment
is often characterised by hard work and the road to recovery is (among
other ...
Chemokines and chemokine receptors during viral infections in man
(2007-11-08)
from HIV-1 infected subjects. In paper II and III, tonsillar B cells were infected with EBV and the expression of CXCR4, CXCR5 and CCR7 was followed over time. Already two days after infection, a decrease of surface CXCR4, CXCR5 and CCR7 was detected...